Związki endokrynnie aktywne i ich aktywność biologiczna

• Authors: Marzena Matejczyk , Patryk Zalewski

Title variants

EN

Endocrine disrupting compounds and its biological activity

• Languages of publication: PL EN

Abstracts

PL

Zanieczyszczenie środowiska naturalnego związkami chemicznymi, pochodzącymi z przemysłu oraz rozwoju nowych technologii nieodłącznie związane jest z wykorzystaniem niebezpiecznych dla zdrowia ludzi substancji, takich jak: polichlorowane bifenyle, dioksyny, pestycydy, fungicydy, herbicydy, składniki wyrobów plastikowych, leki, substancje wykazujące działanie przeciwdrobnoustrojowe oraz przeciwogniowe. Tego rodzaju związki zaliczane są do grupy związków endokrynnie aktywnych (EDCs), mających zdolność modulacji aktywności układu hormonalnego oraz przyczyniających się do rozwoju anomalii reprodukcyjnych. Stąd, istnieje ogromna potrzeba monitorowania oraz ograniczenia niebezpiecznych związków chemicznych w wodach, glebie, powietrzu i żywności. W prezentowanej pracy przeglądowej ogólnie opisano wybrane grupy EDCs, metody ich detekcji oraz ich wpływ na system rozrodczy i metabolizm organizmów żywych.

EN

Contamination of environment with synthetic chemical compounds, originating from the industralisation and technological development, connected with widespread use of hazardous substances such as: pesticides, plasticizers, drugs, antimicrobials, and flame retardants effects on human health. These chemicals called endocrine-disrupting compounds (EDCs) can modulate the activity of endocrine system and result in developmental and reproductive abnormalities. So, there is a need of monitoring and limitation of such dangerous chemicals in food and water. In our review paper the characterization of selected EDCs is presented. Current methods of EDCs detection and potential impact of these compounds on reproductive system development and metabolism are also described.

• Journal: Kosmos
• Year: 2011
• Volume: 60
• Issue: 1-2
• Pages: 17-32

Dates

published

2011

Contributors

author

Marzena Matejczyk

• Politechnika Białostocka, Wydział Budownictwa i Inżynierii Środowiska, Zakład Biologii Sanitarnej i Biotechnologii, Wiejska 45E, 15-351 Białystok, Polska

author

Patryk Zalewski

• Politechnika Białostocka, Wydział Budownictwa i Inżynierii Środowiska, Zakład Biologii Sanitarnej i Biotechnologii, Wiejska 45E, 15-351 Białystok, Polska

References

• Aggarwal B., Bhardwaj A., Aggarwal R., 2004. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 24, 2783-2840.
• Almstrup K., Fernandez M. F., Petersen J. H., Olea N., Skakkebeak N. E., Leffers H., 2002. Dual effects of phytoestrogens in U-shaped does-response curves. Environ. Health Perspec. 110, 743-748.
• Anas M. K., Guillemette C., Ayotte P., Pereg D., Giguere F., Bailey J. L., 2005. In utero and lactationalexposure to an environmentally relevant organochlorine mixture disrupts reproductive developmentand function in male rats. Biol. Reprod. 73, 414-426.
• Andersen H., Vinggaard A., Rasmussen T., 2002. Effects of currently used pesticides in assays for estrogenicity, androgenicity, and aromatase activity in vitro. Toxicol. Appl. Pharmacol. 179, 1-12.
• Andersson A. M., Skakkebaek N. E., 1999. Exposure to exogenous estrogens in food: possible impact on human development and health. Eur. J. Endocrinol. 140, 477-485.
• Aravindakshan J., Gregory M., Marcogliese D. J., Fournier M., Cyr D. G., 2004. Consumption of xenoestrogen - contaminated fish during lactation alters adult male reproductive function. Toxicol. Sci. 81, 179-189.
• Atanassowa N., McKinnel C., Walker M., Turner K. J., Fisher J. S., Morley M., Millar M. R., Groome N. P., Sharpe R. M., 1999. Permanent effects of neonatal estrogen exposure in rats on reproductive hormone levels, Sertoli cell number, and the efficiency of spermatogenesis in adulthood. Endocrinology 140, 5364-5373.
• Batty J., Lim R., 1999. Morphological and reproductive characteristics of male mosquito fish (Gambusia affinis holbrooki) inhabiting sewage-contaminated waters in New South Wales, Australia. Arch. Environ. Contam. Toxicol. 36, 301-307.
• Björkblom C., Salste L., Katsiadaki I., Wiklund T., ronberg L., 2008. Detection of estrogenic activity in municipal wastewater effluent using primary cell cultures from three-spined stickleback and chemical analysis. Chemosphere vol. 73, 1064-1070.
• Blom A., Ekman E., Johannisson A., 1998. Effects of xenoestrogenic environmental pollutants on the proliferation of a human breast cancer cell line (MCF-7). Arch. Environ. Contam. Toxicol. 34, 306-310.
• Bortone S. A, Davis W. P., 1994. Fish intersexuality as indicator of environmental stress. Bioscience 44, 165-172.
• Brian J. V., Harris C. A., Scholze M., Backhaus T., Booyp, Lamoree M., Pojana G., Jonkers N., Runnalls T., Bonfa A., Marcomini A., Sumpter J. P., 2005. Accurate prediction of response of freshwater fish to a mixture of estrogenic chemicals. Environ. Health. Perspec. 113, 721-728.
• Campbell C. G., Borglin S. E., Green F. B., Grayson A., Wozei E., Stringfellow W. T., 2006. Biologically directed environmental monitoring, fate, and transport of estrogenic endocrine disrupting compounds in water. Chemosphere 65,1265-1280.
• Cassidy A., 2003. Potential risks and benefits of phytoestrogen-rich diets. Int. J. Vitam. Nutr. Res. 73, 120-126.
• Chałubiński M, Kowalski M., 2006. Endocrine disrupters - potential modulator of the immune system and allergic response. Allergy 61, 1326-1335.
• Cooke P. S., Naaz A., 2004. Role of estrogens in adipocyte development and function. Exp. Biol. Med. 229, 1127-1135.
• Costa L., 1997. Basic toxicology of pesticides. Occup. Med. 12, 251-268.
• D'Ascenzo G., Di Corcia A., Gentili A., Mancini R., Mastropasqua, R., Nazzari M., Samperi R., 2003. Fate of natural estrogen conjugates in municipal sewage transport and treatment facilities. Sci. Total. Environ. 302, 199-209.
• Delbes G., Levacher C., Habert R., 2006. Estrogen effects on fetal and neonatal testicular development. Reproduction 132, 527-538.
• Denton T. E., Howell W. M., Allison J. J., Mccollum J., Marks B., 1985. Masculinization of female mosquito fish by exposure to plant sterols and Mycobacterium smegmatis. Bull. Environ. Contam. Toxicol. 35, 627-632.
• Desbrow C., Routledge E. J., Brighty G. C., Sumpter J. P., Waldock M., 1998. Identification of Estrogenic Chemicals in STW Effluent. 1. Chemical Fractionation and in Vitro Biological Screening. Environm. Scien. Technol. 32, 1549-1558.
• Falconer I. R., Chapman H. F., Moore M. R., Ranmuthugala G., 2006. Endocrine Disrupting Compounds: A review of their challenge to sustainable and safe water supply and water re-use. J. Environm. Toxicol. 3, 101-112.
• Fernandez M. P., Ikonomou M. G., Buchanan I., 2007. An assessment of estrogenic organic contaminants in Canadian wastewaters. Sci. Total. Environ. 373, 250-269.
• Fisher J., 2004. Are all EDC effects mediated via steroid hormone receptors? Toxicology 205, 33-41.
• Fitzmayer K. M., Geiger J. G., Van Den Avyle M. J., 1982. Effects of chronic exposure to simazine on the cladoceran Daphnia pulex. Arch. Environ. Contam. Toxicol. 11, 603-609.
• Gabet V., Miège C., Bados P., Coquery M., 2007. Analysis of estrogens in environmental matrices, TrAC. Trends Analyt. Chem. 26, 1113-1131.
• Gardiner T., Ramberg J., 2001. Plant estrogens: Importance in health and disease. GlycoScience 2, 1-12.
• Gimeno S., Komen H., Gerritsen A. G. M., Bowmer T., 1998a. Feminisation of young males of the common carp, Cyprinus carpio, exposed to 4-tert-pentylphenol during sexual differentiation. Aquat. Toxicol. 43, 77-92.
• Gimeno S., Komen H., Jobling S., Sumpter J., Bowmer T., 1998b. Demasculinisation of sexually mature male common carp, Cyprinus carpio, exposed to 4-tert-pentylphenol during spermatogenesis. Aquat. Toxicol. 43, 93-109.
• Giusti R. M., Iwamoto K., Hatch E. E., 1995. Diethylstilbestrol revisited: a review of the long-term health effects. Ann. Inter. Med. 122, 778-788.
• Gomes R. L., Birkett J. W., Scrimshaw, M. D., Lester J. N., 2005. Simultaneous determination of natural and synthetic steroid estrogens and their conjugates in aqueous matrices by liquid chromatography/mass spectrometry. Int. J. Environ. Analyt. Chem. 85, 1-14.
• Goyal H. O., Robateau A., Braden T. D., Williams C. S., Srivastava K. K., Ali K., 2003. Neonatal estrogen exposure of male rats alters reproductive functions at adulthood. Biol. Reprod. 68, 2081-2091.
• Greim H. A., 2004. The endocrine and reproductive system; adverse effects of hormonally active substances? Pediatrics 113, 1070-1075.
• Grunfeld H., Bonefeld-Jorgensen E., 2004. Effect of in vitro estrogenic pesticides on human oestrogen receptor alpha and beta mRNA levels. Toxicol. Lett. 151, 467-480.
• Hall L., Rogers J., Denison M., 2005. Identification of the herbicide Surflan and its active ingredient oryzalin, a dinitrosulfonamide, as xenoestrogens. Arch. Environ. Contam. Toxicol. 48, 201-208.
• Harris D., Besselink E., Henning S., 2005. Phytoestrogens induce differential estrogen receptor alpha- or Beta-mediated responses in transfected breast cancer cells. Exp. Biol. Med. 230, 558-568.
• Hofmeister M., Bonefeld-Jorgensen E., 2004. Effects of the pesticides prochloraz and methiocarb on human estrogen receptor alpha and beta mRNA levels analyzed by on-line RTPCR. Toxicol. In Vitro 18, 427-433.
• Irvine C. H., Shand N., Fitzpatrick M. G., Alexander S. L., 1998. Daily intake and urinary excretion of genistein and daidzein by infants fed soy- or dairy-based infant formulas. Am. J. Clin. Nutr. 68, 1462-1465.
• Jobling S., Sheahan D., Osborne J. A., Matthiessen P., Sumpter J. P., 1996. Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals. Environ. Toxicol. Chem. 15, 194-202.
• Joffe M., 2002. Are problems with male reproductive health caused by endocrine disruption? Occup. Environ. Med. 58, 281-290.
• Katase T., Okuda K., Kim Y. S., Eun H., Takada H., Uchiyama T., Saito H., Makino M., Fujimoto Y., 2008. Estrogen equivalent concentration of 13 branched para-nonylphenols in three technical mixtures by isomer-specific determination using their synthetic standards in SIM mode with GC-MS and two new diasteromeric isomers. Chemosphere 70, 1961-1972.
• Kim, Y.S., Katase T., Sekine S., Inoue T., Makino M., Uchiyama T., Fujimoto Y., Yamashita N., 2004. Variation in estrogenic activity among fractions of a commercial nonylphenol by high performance liquid chromatography. Chemosphere 54, 1127-1134.
• Koh Y. K. K., Chiu T. Y., Boobis A., Cartmell E., Lester J. N., Scrimshaw M. D., 2007. Determination of steroid estrogens in wastewater by high performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 1173, 81-87.
• Kolpin D. W., Skopec M., Meyer M. T., Furlong E. T., Zaugg S. D., 2004. Urban contribution of pharmaceuticals and other organic wastewater contaminants to streams during differing flow conditions. Scien. Tot. Environm. 328, 119-130.
• Kris-Etherton P, Hecker K, Bonanome A., 2002. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am. J. Med. 113 (Suppl. 9B), 71-88.
• Kunz P, Fent K., 2006. Multiple hormonal activities of UV filters and comparison of in vivo and in vitro estrogenic activity of ethyl-4-aminobenzoate in fish. Aquat. Toxicol. 79, 305-324.
• Kurzer M., 2003. Phytoestrogen supplement use by women. J. Nutr. 133, 1983S-1986S.
• Latch D. E., Packer J. L., Arnold W. A., Mcneill K., 2003. Photochemical conversion of Triclosan to 2,8-dichlorodibenzo-p-dioxin in aqueous solution. J. Photochem. Photobiol. Anal. Chem. 158, 63-66.
• Leffers H, Neasby M, Vandelbo B, Skakkebeak N. E., Jorgensen M., 2001. Oestrogenic potencies of zeranol, estradiol, diethylstilbestrol, bisfenol A, and genistein: implications for exposure assessment of potential endocrine disruptors. Hum. Reprod. 16, 1037-1045.
• Lemaire G., Mnif W., Mauvais P., 2006. Activation of alpha- and beta-estrogen receptors by persistent pesticides in reporter cell lines. Life Sci. 79, 1160-1169.
• Limer J., Speirs V., 2004. Phyto-oestrogens and breast cancer chemoprevention. Breast Canc. Res. 6, 119-127.
• Maras M., Vanparys C., Muylle F., 2006. Estrogen-like properties of fluorotelomer alcohols as revealed by mcf-7 breast cancer cell proliferation. Environ. Health Perspect. 114, 100-105.
• Martin M., Reiter R., Pham T., 2003. Estrogen-like activity of metals in MCF-7 breast cancer cells. Endocrinology 144, 2425-2436.
• Matsumura A., Ghosh A., Pope G., 2005. Comparative study of oestrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells. J. Steroid. Biochem. Mol. Biol. 94, 431-443.
• McLachlan J. A., 2001. Environmental signaling: what embryos and evolution teach us about endocrine disrupting chemicals. Endocr. Rev. 22, 319-341.
• Merritt R. J., Jenks B. H., 2004. Safety of soy based infant formulas containing isoflavones: the clinical evidence. J. Nutr 134, 1220-1224.
• Minervini F., Giannoccaro A., Cavallini A., 2005. Investigations on cellular proliferation induced by zearalenone and its derivatives in relation to the estrogenic parameters. Toxicol. Lett. 159, 272-283.
• Morito K., Aomori T., Hirose T., Kinjo J., Hasegawa J., Ogawa S., Inoue S., Muramatsu M., Masamune Y., 2002. Interaction of phytoestrogens with estrogen receptors alpha and beta (II). Biol. Pharm. Bull. 25, 48-52.
• Mueller S., 2004. Xenoestrogens: mechanisms of action and detection methods. Anal. Bioanal. Chem. 378, 582-587.
• Murkies A. L., Wilcox G., Davis S. R., 1998. Clinical review 92. Phytoestrogens. J. Clin. Endocrinol. Metab. 83, 297-303.
• Newbold R. R., Padilla-Banks E., Snyder R. J., Jefferson W. N., 2007b. Perinatal exposure to environmental estrogens and the development of obesity. Mol. Nutr. Food Res. 51, 912-917.
• Newbold R. R., Padilla-Banks E., Snyder R. J., Phillips T. M., Jefferson W. N., 2007a. Developmental exposure to endocrine disruptors and the obesity epidemic. Reprod. Toxicol. 23, 290-296.
• Nieto A., Borrull F., Pocurull E., Marcé R. M., 2008. Determination of natural and synthetic estrogens and their conjugates in sewage sludge by pressurized liquid extraction and liquid chromatography-tandem mass spectrometry. J. Chromat. A 1213, 224-230.
• Nimrod A., C., Benson W. H., 1998. Reproduction and development of Japanese edaka following an early life stage exposure to xenoestrogens. Aquat. Toxicol. 44, 141-156.
• Panicker R. C., Chattopadhaya S., Yao S. Q., 2006. Advanced analytical tools in proteomics. Analytica. Chimica. Acta. 556, 69-79.
• Petrovic M., Barcelo D., 2000. Determination of Anionic and Nonionic Surfactants, Their Degradation Products, and Endocrine-Disrupting Compounds in Sewage Sludge by Liquid Chromatography/Mass Spectrometry. Anal. Chem. 72, 4560-4567.
• Rankouhi T. R., Van Holsteijn I., Letcher R., Giesy J. P., Van Den Berg M., 2002. Effects of Primary Exposure to Environmental and Natural Estrogens on Vitellogenin Production in Carp (Cyprinus carpio) Hepatocytes. Toxicol. Sci. 67, 75-80.
• Rhouma K. B., Tébourbi O., Krichah R., Sakly M., 2001. Reproductive toxicity of DDT in adult male rats. Hum. Exp. Toxicol. 20, 393-397.
• Robertson K. M., Odonnell L., Simpson E. R., Jones M. E., 2002. The phenotype of the aromatase knockout mouse reveals dietary phytoestrogens impact significantly on testis function. Endocrinology 143, 2913-2921.
• Rochira V., Granata A. R., Madeo B., Zirilli L., Rossi G., Carani C., 2005. Estrogens in males: what have we learned in the last 10 years? Asian. J. Androl. 7, 3-20.
• Rosselli M., Reinhart K., Imthurn B., Keller P. J., Dubey R. K. 2000. Cellular and biochemical mechanisms by which environmental oestrogens influence reproductive function. Hum. Reprod. Update. 6, 332-350.
• Routledge E. J., Sumpter J. P., 1997. Structural features of alkylphenolic chemicals associated with estrogenic activity. J. Biol. Chem. 272, 3280-3288.
• Sanderson J., Boerma J., Lansbergen G., 2002. Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells. Toxicol. Appl. Pharmacol. 182, 44-54.
• Seńczuk W. (red.), 2002. Toksykologia pestycydów. [W:] Toksykologia. Warszawa, Wydawnictwo Lekarskie PZWL, 538-544, 615-617.
• Setchell K. D., 2001. Soy isoflavons . benefits and risks from nature's Selective Estrogen Receptor Modulators (SERMs). Am. J. Clin. Nutr. 20, 354-362.
• Sharpe R. M., 2001. Hormones and testis development and possible adverse effects of environmental chemicals. Toxicol. Lett. 120, 221-232.
• Sharpe R. M., Irvine D. S., 2001. Clinical review. How strong is the evidence of a link between environmental chemicals and adverse effects on human reproductive health? Br. Med. J. 328, 447-451.
• Soto A. M., Calabro J. M., Prechtl N. V., Yau A. Y., Orlando E. F., Daxenberger A., Kolok A. S., Guillette L. J., Le Bizec B., Lange I. G., Sonnenschein C., 2004. Androgenic and estrogenic activity in water bodies receiving cattle feedlot effluent in eastern Nebraska USA. Environ. Health. Perspec. 112, 346-352.
• Stoica A., Pentecost E., Martin M., 2000. Effects of arsenite on estrogen receptor-alpha expression and activity in MCF-7 breast cancer cells. Endocrinol. 141, 3595-3602.
• Sumpter J. P., 2005. Endocrine disrupters in the aquatic environment: an overview. Acta. Hydrochim. Hydrobiol. 33, 9-16.
• Ternes, T. A., Stumpf M., Mueller J., Haberer K., Wilken R. D., Servos M., 1999. Behavior and occurrence of estrogens in municipal sewage treatment plants - I. Investigations in Germany, Canada and Brazil. Sci. Total Environ. 225, 81-90.
• Toppari J., Haavisto A. M., Alanen M., 2002. Changes in male reproductive health and effects of endocrine disruptors in Scandinavian countries. Cad. Saude. Publica. 18, 413-420.
• Toyama Y., Suzuki-Toyota F., Maekawa M, Ito C, Toshimori K., 2004. Adverse effects of bisphenol A to spermiogenesis in mice and rats. Arch. Histol. Cytol. 67, 373-381.
• Turner K. J., Sharpe R. M., 1997. Environmental oestrogens - present understanding. Rev. Reprod. 2, 69-73.
• Usui T., 2006. Pharmaceutical prospects of phytoestrogens. Endocr J. 53, 7-20.
• Van Den Belt K., Berckmans P., Vangenechten C., Verheyen R., Witters H., 2004. Comparative study on the in vitro/in vivo estrogenic potencies of 17[beta]-estradiol, estrone, 17[alpha]-ethynylestradiol and nonylphenol. Aquat. Toxicol. 66, 183-195.
• Vanparys C., Maras M., Lenjou M., 2006. Flow cytometric cell cycle analysis allows for rapid screening of estrogenicity in MCF-7 breast cancer cells. Toxicol. in Vitro 20, 1238-1248.
• Wada K., Sakamoto H., Nishikawa K., Sakuma S., Nakajima A., Fujimoto Y., Kamisaki Y., 2007. Life style-related diseases of the digestive system: Endocrine disruptors stimulate lipid accumulation in target cells related to metabolic syndrome. J. Pharmacol. Sci. 105, 133-137.
• Waring R., Harris R., 2005. Endocrine disrupters: a human risk? Mol. Cell. Endocrinol. 244, 2-9.
• Weber K. S., Setchell K. D., Stocco D. M., Lephard E. D., 2001. Dietary soy phytoestrogens decrease testosterone levels and prostate weight without altering LH, prostate reductase or testicular steroidogenic acute regulatory peptide levels in adult male Sprague - Downey rats. J.Endocrinol. 170,591-599.
• Weyer P., Riley D., 2001. Endocrine disruptors and pharmaceuticals in drinking water. Denver, CO: AWWA Research Foundation and The American Water Works Association.
• Wiśniewski A. B., Klein S. L., Lakshamanan Y., Gearhart J. P. 2003. Exposure to genistein Turing gestation and lactation demasculinizes the reproductive system in rats. J Urolog. 169, 1582-1586.
• Witorch R. J., 2002. Endocrine disruptors: can biological effects and environmental risks be predicted? Regul. Toxicol. Pharmacol. 36, 118-130.
• Wober J., Weisswange I., Vollmer G., 2002. Stimulation of alkaline phosphatase activity in Ishikawa cells induced by various phytoestrogens and synthetic estrogens. J. Steroid. Biochem. Mol. Biol. 83, 227-233.
• Yamada, K. M., 2008. Whole Organism and Tissue Analysis. Current Protocols in Cell Biology. Wiley Online Library 41:19.0.1-9.0.2.