Białka kompleksu ADF/kofilina: regulacja dynamiki filamentów aktynowych

• Authors: Aleksandra Stępień , Alina Grzanka , Maciej Ostrowski

Title variants

EN

Proteins of the ADF/cofilin family: regulation of actin filaments dynamics

• Languages of publication: PL EN

Abstracts

EN

Many cellular events are directly related to the cytoskeleton’s dynamics, which remain under control of the protein regulatory system. Proteins of the ADF/cofilin family have been shown to be active in depolymerizing F-actin, as well as severing actin filaments and creating free barbed ends. Their various functions are regulated, among others, by phosphorylation, pH, the state of the nucleotide bound profilin, gelsolin, tropomyosin, AIP1 and the Arp 2/3 complex. In addition, the ability of ADF/cofilin to bind to actin appears to be modified by phalloidin. It has also been emphasized that these key actin dynamics’ regulators are able to form intranuclear actin/cofilin rods and some of their activities are associated with apoptosis.

• Journal: Kosmos
• Year: 2005
• Volume: 54
• Issue: 4
• Pages: 381-389

Dates

published

2005

Contributors

author

Aleksandra Stępień

• Uniwersytet Mikołaja Kopernika w Toruniu Collegium Medicum im. L. Rydygiera w Bydgoszczy Katedra i Zakład Histologii i Embriologii, Karłowicza 24, 85-092 Bydgoszcz, Polska

author

Alina Grzanka

• Uniwersytet Mikołaja Kopernika w Toruniu Collegium Medicum im. L. Rydygiera w Bydgoszczy Katedra i Zakład Histologii i Embriologii, Karłowicza 24, 85-092 Bydgoszcz, Polska

author

Maciej Ostrowski

• Uniwersytet Mikołaja Kopernika w Toruniu Collegium Medicum im. L. Rydygiera w Bydgoszczy Katedra i Zakład Histologii i Embriologii, Karłowicza 24, 85-092 Bydgoszcz, Polska

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