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Journal

2005 | 54 | 4 | 381-389

Article title

Białka kompleksu ADF/kofilina: regulacja dynamiki filamentów aktynowych

Content

Title variants

EN
Proteins of the ADF/cofilin family: regulation of actin filaments dynamics

Languages of publication

PL EN

Abstracts

EN
Many cellular events are directly related to the cytoskeleton’s dynamics, which remain under control of the protein regulatory system. Proteins of the ADF/cofilin family have been shown to be active in depolymerizing F-actin, as well as severing actin filaments and creating free barbed ends. Their various functions are regulated, among others, by phosphorylation, pH, the state of the nucleotide bound profilin, gelsolin, tropomyosin, AIP1 and the Arp 2/3 complex. In addition, the ability of ADF/cofilin to bind to actin appears to be modified by phalloidin. It has also been emphasized that these key actin dynamics’ regulators are able to form intranuclear actin/cofilin rods and some of their activities are associated with apoptosis.

Keywords

Journal

Year

Volume

54

Issue

4

Pages

381-389

Physical description

Dates

published
2005

Contributors

  • Uniwersytet Mikołaja Kopernika w Toruniu Collegium Medicum im. L. Rydygiera w Bydgoszczy Katedra i Zakład Histologii i Embriologii, Karłowicza 24, 85-092 Bydgoszcz, Polska
author
  • Uniwersytet Mikołaja Kopernika w Toruniu Collegium Medicum im. L. Rydygiera w Bydgoszczy Katedra i Zakład Histologii i Embriologii, Karłowicza 24, 85-092 Bydgoszcz, Polska
  • Uniwersytet Mikołaja Kopernika w Toruniu Collegium Medicum im. L. Rydygiera w Bydgoszczy Katedra i Zakład Histologii i Embriologii, Karłowicza 24, 85-092 Bydgoszcz, Polska

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Publication order reference

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bwmeta1.element.bwnjournal-article-ksv54p381kz
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