Neuroprzekaźnik hamujący w plastyczności kory mózgu

• Authors: Ewa Siucińska

Title variants

EN

Inhibitory neurotransmitter in cerebral cortex plasticity

• Languages of publication: PL EN

Abstracts

EN

The evidence accumulated in the past fifty years indicates that γ-aminobutyric acid (GABA) is a widely distributed inhibitory neurotransmitter present in the interneurons and synaptic terminals in mammalian brain. GABA acts on at least two distinct ionotropic receptors: GABAA,C and metabotropic receptor GABAB. This paper reviews the data that pertain to the role played by GABA in neocortical plasticity. Emphasis is given to GABA synthesis, GABA in the cellular and extracellular regulation, GABA receptors and GABA interneuron distribution, analyzed by various means. These include: anatomical, electrophysiological responses, ligand binding as revealed by receptor autoradiography, and expression of GAD65, GAD67 at both mRNA and protein (immunoreactivity) levels. Possible mechanisms of involvement of GABA in plastic changes of cortical neuron's response are reviewed, and data on up- and down regulation of GABAA receptors in neocortical plasticity are summarized. Mechanisms involving GABA in cortical plasticity of adult and neonatal animals are discussed.

• Journal: Kosmos
• Year: 2005
• Volume: 54
• Issue: 2-3
• Pages: 195-212

Dates

published

2005

Contributors

author

Ewa Siucińska

• Zakład Neurobiologii Molekularnej i Komórkowej Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Pasteura 3, 02-093 Warszawa, Polska

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