Zależna od ubikwityny degradacja białek Nagroda Nobla z chemii w 2004 roku

• Authors: Barbara Grzelakowska-Sztabert

Title variants

EN

Nobel Prize in chemistry in 2004 for ubiquitin-dependent protein degradation

• Languages of publication: PL EN

Abstracts

EN

In the article Nobel laureates in chemistry for 2004 - Irvine Rose, Avram Hershko and Aron Ciechanover - and their achievements in elucidating the ubiquitin-mediated protein degradation are presented and the function of ubiquitin in this process is shortly reviewed. Moreover, ubiquitin ligases involved in the ubiquitylation of the main cell cycle regulators as well as the mechanisms regulated by their activities are described. Examples of the abnormalities of functioning of the ubiquitin/proteasome system in various diseases and possibilities of pharmacological intervension in its action are also presented.

• Journal: Kosmos
• Year: 2005
• Volume: 54
• Issue: 2-3
• Pages: 133-148

Dates

published

2005

Contributors

author

Barbara Grzelakowska-Sztabert

• Zakład Biochemii Komórki Instytut Biologii Doświadczalnej im. M. Nenckiego, PAN, Pasteura 3, 02-093 Warszawa, Polska

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