Comparison of Iron Oxide-Related MRI Artifacts in Healthy and Neuropathological Human Brain Tissue

• Authors: M. Masarova , A. Krafcik , M. Teplan , O. Strbak , D. Gogola , P. Boruta , D. Dobrota , I. Frollo
• Languages of publication: EN

Abstracts

EN

The aim of this study is to clarify whether clinical magnetic resonance imaging data can be utilised to evaluate the pathological processes associated with disrupted iron homeostasis, such as neurodegenerative processes or cirrhosis. Although MRI has the potential to become a non-invasive biomarker of such pathology, new quantification methods must be introduced. Our findings confirmed that it is possible to detect significant difference between healthy and pathological tissue from standard T2 weighted MRI protocols.

Keywords

EN

87.61.Ff; 75.50.Cc; 87.19.xr; 87.19.xe

Discipline

• 87.61.Ff: Instrumentation
• 87.19.xe: Parasitic diseases
• 87.19.xr: Degenerative diseases (Alzheimer's, ALS, etc)
• 75.50.Cc: Other ferromagnetic metals and alloys

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2017
• Volume: 131
• Issue: 4
• Pages: 1108-1110

Dates

published

2017-04

Contributors

author

M. Masarova

• Institute of Measurement Science, SAS, Dubravska cesta 9, 841 05 Bratislava, Slovakia

author

A. Krafcik

• Institute of Measurement Science, SAS, Dubravska cesta 9, 841 05 Bratislava, Slovakia

author

M. Teplan

• Institute of Measurement Science, SAS, Dubravska cesta 9, 841 05 Bratislava, Slovakia

author

O. Strbak

• Institute of Measurement Science, SAS, Dubravska cesta 9, 841 05 Bratislava, Slovakia
• Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia

author

D. Gogola

• Institute of Measurement Science, SAS, Dubravska cesta 9, 841 05 Bratislava, Slovakia

author

P. Boruta

• Slovak Medical University, Limbova 12, 833 03 Bratislava, Slovakia

author

D. Dobrota

• Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia

author

I. Frollo

• Institute of Measurement Science, SAS, Dubravska cesta 9, 841 05 Bratislava, Slovakia

References

• [1] P. Dusek, M. Dezortova, J. Wuerfel, Int. Rev. Neurobiol. 110, 195 (2013), doi: 10.1016/B978-0-12-410502-7.00010-7
• [2] C.B. Sirlin, S.B. Reeder, Magn. Reson. Imaging Clin. N. Am. 18, 359 (2010), doi: 10.1016/j.mric.2010.08.014
• [3] G. Bartzokis, D. Sultzer, J. Cummings, L.E. Holt, D.B. Hance, V.W. Henderson, J. Mintz, Arch. Gen. Psychiatry 57, 47 (2000), doi: 10.1001/archpsyc.57.1.47
• [4] L.H. You, F. Li, L. Wang, S.E. Zhao, S.M. Wang, L.L. Zhang, L.H. Zhang, X.L. Duan, P. Yu, Y.Z. Chang, Neuroscience 284, 234 (2015), doi: 10.1016/j.neuroscience.2014.09.071
• [5] J. Galazka-Friedman, A. Friedman, E.R. Bauminger, Hyperfine Interact. 189, 31 (2009), doi: 10.1007/s10751-009-9926-7
• [6] M. Khalil, C. Langkammer, A. Pichler, D. Pinter, T. Gattringer, G. Bachmaier, S. Ropele, S. Fuchs, C. Enzinger, F. Fazekas, Neurology 84, 24 (2015), doi: 10.1212/WNL.0000000000001679
• [7] D.A. Burton, Composite Standard Deviations, (accessed: 30 May 2016) http://www.burtonsys.com/climate/composite_standard_deviations.html

Identifiers

DOI

10.12693/APhysPolA.131.1108