Catecholase-Like Activity Studies of Tc-99m Radiopharmaceuticals

• Authors: E. Cicek , B. Dede
• Languages of publication: EN

Abstracts

EN

Catechol oxidase catalyses the oxidation of a broad range of catechols to the corresponding o-quinones through the four-electron reduction of molecular oxygen to water, without acting on tyrosine. The resulting highly reactive quinones autopolymerize to form brown polyphenolic catechol melanins, a process thought to protect the damaged plant against pathogens or insects. This work describes the catalytic activity of some radiopharmaceuticals like Tc-99m pertechnetate, Tc-99m mercaptoacetyltriglycine (MAG3), Tc-99m nanocolloid, Tc-99m methylenebis(phosphonic acid) (MDP) and Tc-99m methoxyisobutylisonitrile (MIBI) for oxidation of catechol. The catalytic oxidation of 3,5-di-tert-butylcatechol by selected radiopharmaceuticals saturated with molecular oxygen was studied in a homogeneous system. All the radiopharmaceuticals exhibited catecholase-like activity.

Keywords

EN

87.57.uk

Discipline

• 87.57.uk: Positron emission tomography (PET)

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2016
• Volume: 129
• Issue: 2
• Pages: 213-215

Dates

published

2016-02

Contributors

author

E. Cicek

• Faculty of Science and Art, Mehmet Akif Ersoy University, Burdur, Turkey

author

B. Dede

• Faculty of Science and Art, Süleyman Demirel University, Isparta, Turkey

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Identifiers

DOI

10.12693/APhysPolA.129.213