The Study of Human Osteoblast-Like MG 63 Cells Proliferation on Resorbable Polymer-Based Nanocomposites Modified with Ceramic and Carbon Nanoparticles

• Authors: A. Wiecheć , E. Stodolak-Zych , A. Frączek-Szczypta , M. Błażewicz , W. Kwiatek
• Languages of publication: EN

Abstracts

EN

Polymer-based nanocomposites containing biocompatible and bioactive nanocomponents seem to be excellent materials that could be used in many biomedical applications. The aim of this study was biological evaluation of resorbable polymer-based nanocomposites (PLA, PCL) and their modifications with ceramic nanoparticles (silica - SiO_2, montmorillonite - MMT) or carbon nanotubes. The nanocomposites were seeded with the human osteoblast-like MG 63 cells. After 1, 3 and 7 days of incubation, Trypan blue exclusion test was used to determine the viability and number of cells. The cell population density depending on incubation time and cell population doubling time was calculated. The cell proliferation abilities on the all applied nanocomposites and on control material (polystyrene cell culture plate) were also compared. The number of cells growing on the nanocomposite surfaces increased with the incubation time. The cell viability was not decreased for all applied materials during the entire study (97-100%). The ceramic nanoparticles and carbon nanotubes modified the bone cell growth and proliferation rate. Results of this study confirm that all types of the nanocomposites are appropriate to the growing and proliferation of human osteoblast-like cells.

Keywords

EN

82.35.Np; 87.17.Ee

Discipline

• 82.35.Np: Nanoparticles in polymers(see also 81.07.-b Nanoscale materials and structures: fabrication and characterization)
• 87.17.Ee: Growth and division

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2012
• Volume: 121
• Issue: 2
• Pages: 546-550

Dates

published

2012-02

Contributors

author

A. Wiecheć

• The Henryk Niewodniczański Institute of Nuclear Physics, Polish Academy of Sciences, Kraków, Poland

author

E. Stodolak-Zych

• Faculty of Material Science and Ceramic, Department of Biomaterials, AGH-University of Science and Technology, Kraków, Poland

author

A. Frączek-Szczypta

• Faculty of Material Science and Ceramic, Department of Biomaterials, AGH-University of Science and Technology, Kraków, Poland

author

M. Błażewicz

• Faculty of Material Science and Ceramic, Department of Biomaterials, AGH-University of Science and Technology, Kraków, Poland

author

W. Kwiatek

• The Henryk Niewodniczański Institute of Nuclear Physics, Polish Academy of Sciences, Kraków, Poland

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Identifiers

DOI

10.12693/APhysPolA.121.546