Clinical, biochemical and genetic risk factors for 30-day and 5-year mortality in 518 adult patients subjected to cardiopulmonary bypass during cardiac surgery - the INFLACOR study

• Authors: Maciej Kowalik , Romuald Lango , Piotr Siondalski , Magdalena Chmara , Maciej Brzeziński , Krzysztof Lewandowski , Dariusz Jagielak , Andrzej Klapkowski , Jan Rogowski
• Languages of publication: EN

Abstracts

EN

There is increasing evidence that genetic variability influences patients' early morbidity after cardiac surgery performed using cardiopulmonary bypass (CPB). The use of mortality as an outcome measure in cardiac surgical genetic association studies is rare. We publish the 30-day and 5-year survival analyses with focus on pre-, intra-, postoperative variables, biochemical parameters, and genetic variants in the INFLACOR (INFLAmmation in Cardiac OpeRations) cohort. In a prospectively recruited cohort of 518 adult Polish Caucasians, who underwent cardiac surgery in which CPB was used, the clinical data, biochemical parameters, IL-6, soluble ICAM-1, TNFα, soluble E-selectin, and 10 single nucleotide polymorphisms were evaluated for their association with 30-day and 5-year mortality. The 30-day mortality was associated with: pre-operative prothrombin international normalized ratio, intra-operative blood lactate, postoperative serum creatine phosphokinase, and acute kidney injury requiring renal replacement therapy (AKI-RRT) in logistic regression. Factors that determined the 5-year survival included: pre-operative NYHA class, history of peripheral artery disease and severe chronic obstructive pulmonary disease, intra-operative blood transfusion; and postoperative peripheral hypothermia, myocardial infarction, infection, and AKI-RRT in Cox regression. Serum levels of IL-6 and ICAM-1 measured three hours after the operation were associated with 30-day and 5-year mortality, respectively. The ICAM1 rs5498 was associated with 30-day and 5-year survival with borderline significance. Different risk factors determined the early (30-day) and late (5-year) survival after adult cardiac surgery in which cardiopulmonary bypass was used. Future genetic association studies in cardiac surgical patients should account for the identified chronic and perioperative risk factors.

Keywords

EN

cardiac surgery; cardiopulmonary bypass; 30-day mortality; 5-year mortality; ICAM1 rs5498; ICAM-1; renal replacement therapy.

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2018
• Volume: 65
• Issue: 2
• Pages: 241-250

Dates

published

2018

received

2017-11-20

revised

2018-03-10

accepted

2018-03-10

(unknown)

2018-04-25

Contributors

author

Maciej Kowalik

• Department of Cardiac Anesthesiology, Medical University of Gdansk, Gdańsk, Poland

author

Romuald Lango

• Department of Cardiac Anesthesiology, Medical University of Gdansk, Gdańsk, Poland

author

Piotr Siondalski

• Department of Cardiac and Vascular Surgery, Medical University of Gdansk, Gdańsk, Poland

author

Magdalena Chmara

• Department of Biology and Genetics, Medical University of Gdansk, Gdańsk, Poland

author

Maciej Brzeziński

• Department of Cardiac and Vascular Surgery, Medical University of Gdansk, Gdańsk, Poland

author

Krzysztof Lewandowski

• Department of Clinical Chemistry and Biochemistry, Medical University of Gdansk, Gdańsk, Poland

author

Dariusz Jagielak

• Department of Cardiac and Vascular Surgery, Medical University of Gdansk, Gdańsk, Poland

author

Andrzej Klapkowski

• Department of Cardiac and Vascular Surgery, Medical University of Gdansk, Gdańsk, Poland

author

Jan Rogowski

• Department of Cardiac and Vascular Surgery, Medical University of Gdansk, Gdańsk, Poland

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Identifiers

DOI

10.18388/abp.2017_2361