Nano-emulsions as vehicles for topical delivery of forskolin

• Authors: Małgorzata Miastkowska , Elżbieta Sikora , Elwira Lasoń , Maria Garcia-Celma , Elvira Escribano-Ferrer , Conxita Solans , Meritxell Llinas
• Languages of publication: EN

Abstracts

EN

Two O/W forskolin-loaded nano-emulsions (0.075% wt.) based on medium chain triglycerides (MCT) and stabilized by a nonionic surfactant (Polysorbate 80 or Polysorbate 40) were studied as forskolin delivery systems. The nano-emulsions were prepared by the PIC method. The mean droplet size of the nano-emulsions with Polysorbate 80 and Polysorbate 40 with oil/surfactant (O/S) ratios of 20/80 and 80% water concentration, measured by Dynamic Light Scattering (DLS), was of 118 nm and 111 nm, respectively. Stability of the formulations, as assessed by light backscattering for 24 h, showed that both nano-emulsions were stable at 25°C. Studies of forskolin in vitro skin permeation from the nano-emulsions and from a triglyceride solution were carried out at 32°C, using Franz-type diffusion cells. A mixture of PBS/ethanol (60/40 v/v) was used as a receptor solution. The highest flux and permeability coefficient was obtained for the system stabilized with Polysorbate 80 (6.91±0.75 µg · cm-2·h-1 and 9.21 · 10-3±1.00 · 10-3 cm · h-1, respectively) but no significant differences were observed with the flux and permeability coefficient value of forskolin dissolved in oil. The obtained results showed that the nano-emulsions developed in this study could be used as effective carriers for topical administration of forskolin.

Keywords

EN

Forskolin; nano-emulsions; medium chain triglycerides; in vitro skin permeation

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2017
• Volume: 64
• Issue: 4
• Pages: 713-718

Dates

published

2017

received

2017-10-05

revised

2017-11-13

accepted

2017-11-19

(unknown)

2017-12-13

Contributors

author

Małgorzata Miastkowska

• Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland

author

Elżbieta Sikora

• Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland

author

Elwira Lasoń

• Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland

author

Maria Garcia-Celma

• Pharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain, IN2UB members

author

Elvira Escribano-Ferrer

• Pharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain, IN2UB members

author

Conxita Solans

• Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC) and CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain

author

Meritxell Llinas

• Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC) and CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain

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Identifiers

DOI

10.18388/abp.2017_2334