Vitamin D status in patients with rheumatoid arthritis: a correlation analysis with disease activity and progression, as well as serum IL-6 levels

• Authors: Kinga Polasik , Ewa Piotrowska , Barbara Lipińska , Jacek Witkowski , Ewa Bryl , Stefan Tukaj
• Languages of publication: EN

Abstracts

EN

Objectives. Recent epidemiological studies suggested an association between a poor vitamin D [25(OH)D] status, inflammatory mediators, and rheumatoid arthritis (RA). We have recently proposed that pro-inflammatory interleukin 6 (IL-6) may represent a good marker for disease activity of RA. The aim of this study was to investigate the relationship between serum 25(OH)D levels and disease activity, joint damage, as well as serum IL-6 levels in a Polish RA population. Materials and Methods. Serum 25(OH)D levels were measured in 35 female RA patients and 38 age- and gender-matched healthy controls. Statistical correlations between 25(OH)D levels and the disease activity score 28 (DAS 28), joint damage based on the Steinbrocker criteria, as well as serum IL-6 levels were performed. Results. There was no statistically significant difference between levels of 25(OH)D in RA (16.89±8.57 ng/ml) and healthy controls (14.12±7.51 ng/ml), and the vitamin D deficiency (<20 ng/ml) was found in 71.43% of RA patients and 73.68 % of healthy controls. While vitamin D status did not correlate with DAS 28 (r=0.265, p=0.149) and joint damage based on the Steinbrocker criteria (r=0.367, p=0.065), a positive correlation between 25(OH)D and IL-6 (r=0.537, p=0.002) was observed in RA. Conclusion. Although further studies on a larger group of patients will be needed to confirm the data presented here, it seems that hypovitaminosis D is common in the RA patients and middle-aged non-RA healthy women in the Polish population. 25(OH)D levels were similar in the RA patients and age- and gender-matched healthy controls, and were not associated with joint damage and disease activity in patients.

Keywords

EN

rheumatoid arthritis; vitamin D deficiency; 25(OH)D; IL-6

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2017
• Volume: 64
• Issue: 4
• Pages: 667-670

Dates

published

2017

received

2017-06-30

revised

2017-09-12

accepted

2017-09-13

(unknown)

2017-12-05

Contributors

author

Kinga Polasik

• Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland

author

Ewa Piotrowska

• Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland

author

Barbara Lipińska

• Department of General and Medical Biochemistry, Faculty of Biology, University of Gdańsk, Gdańsk, Poland

author

Jacek Witkowski

• Department of Pathophysiology, Medical University of Gdańsk, Gdańsk, Poland

author

Ewa Bryl

• Department of Pathology and Experimental Rheumatology, Medical University of Gdańsk, Gdańsk, Poland

author

Stefan Tukaj

• Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland

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Identifiers

DOI

10.18388/abp.2017_1636