Serum levels of the S100B protein and neuron-specific enolase are associated with mortality in critically ill patients

• Authors: Izabela Duda , Łukasz Krzych , Halina Jędrzejowska-Szypułka , Joanna Lewin-Kowalik
• Languages of publication: EN

Abstracts

EN

Introduction. Evaluation of the prognostic potential of the S100B protein and neuron-specific enolase (NSE) as predictors of mortality in critically ill patients in intensive care units (ICU). Materials and Methods. The study was conducted on 62 patients. Basic clinical variables and blood samples for S100B and NSE level testing were obtained during the first four days after admission. Mortality was described as the patient's death during hospitalization in the ICU. Results. 35% of the patients had died. The level of S100B and NSE was significantly higher in non-survivors in comparison with survivors (p=0.007 and p=0.02, respectively). Mortality risk was significantly higher in patients with higher levels of biomarkers than the reference values for S100B (OR 9.00; 95% CI 2.38-33.99; p<0.001) as well as for NSE (OR 5.75; 95%CI 1.31-25.27; p=0.016). Receiver operating characteristic proved that S100B is a better mortality predictor than NSE (AUC 0.76 for S100B and 0.68 for NSE). From all the other variables, the Apache II score turned out to be the only significant predictor of mortality (AUC 0.88). Conclusion. There is a significant correlation between mortality in the ICU and increased serum concentration of S100B and NSE. This correlation is stronger for S100B. Testing for serum levels of S100B and NSE may be useful for prediction of treatment outcomes in the ICU patients.

Keywords

EN

S100B; neuron-specific enolase; mortality; critically ill

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2017
• Volume: 64
• Issue: 4
• Pages: 647-652

Dates

published

2017

received

2017-06-07

revised

2017-08-18

accepted

2017-10-16

(unknown)

2017-12-10

Contributors

author

Izabela Duda

• Department of Anesthesiology and Intensive Care, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

author

Łukasz Krzych

• Department of Anesthesiology and Intensive Care, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

author

Halina Jędrzejowska-Szypułka

• Department of Physiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

author

Joanna Lewin-Kowalik

• Department of Physiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Identifiers

DOI

10.18388/abp.2017_1619