Ionizing radiation affects profile of serum metabolites: increased level of 3-hydroxybutyric acid in serum of cancer patients treated with radiotherapy

• Authors: Małgorzata Roś-Mazurczyk , Anna Wojakowska , Łukasz Marczak , Krzysztof Polański , Monika Pietrowska , Karol Jelonek , Iwona Domińczyk , Agata Hajduk , Tomasz Rutkowski , Krzysztof Składowski , Piotr Widłak
• Languages of publication: EN

Abstracts

EN

Radiotherapy causes molecular changes observed at the level of body fluids, which are potential biomarker candidates for assessment of radiation exposure. Here we analyzed radiotherapy-induced changes in a profile of small metabolites detected in sera of head and neck cancer patients using the gas chromatography coupled with mass spectrometry approach. There were about 20 compounds, including carboxylic acids, sugars, amines and amino acids, whose levels significantly differed between pre-treatment and post-treatment samples. Among metabolites upregulated by radiotherapy there was 3-hydroxybutyric acid, whose level increased about three times in post-treatment samples. Moreover, compounds affected by irradiation were associated with several metabolic pathways, including protein biosynthesis and amino acid metabolism.

Keywords

EN

head and neck cancer; mass spectrometry; metabolomics; radiation response; serum metabolome

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2017
• Volume: 64
• Issue: 1
• Pages: 189-193

Dates

published

2017

received

2016-04-11

revised

2016-05-06

accepted

2016-07-14

(unknown)

2016-11-04

Contributors

author

Małgorzata Roś-Mazurczyk

• Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland

author

Anna Wojakowska

• Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland

author

Łukasz Marczak

• Institute of Bioorganic Chemistry Polish Academy of Sciences, Poznań, Poland

author

Krzysztof Polański

• Warwick Systems Biology Centre, University of Warwick, Warwick, United Kingdom

author

Monika Pietrowska

• Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland

author

Karol Jelonek

• Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland

author

Iwona Domińczyk

• Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland

author

Agata Hajduk

• Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland

author

Tomasz Rutkowski

• Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland

author

Krzysztof Składowski

• Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland

author

Piotr Widłak

• Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland

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Identifiers

DOI

10.18388/abp.2016_1301