Mitochondrial DNA in pediatric leukemia patients

• Authors: Agata Kodroń , Magda Ghanim , Katarzyna Krawczyk , Anna Stelmaszczyk-Emmel , Katarzyna Tońska , Urszula Demkow , Ewa Bartnik
• Languages of publication: EN

Abstracts

EN

Numerous studies of mitochondrial DNA (mtDNA) in cancer have shown differences between mtDNA sequences in tumor and normal tissue and at various stages of cancer treatment in the same patient. However, there is little data on acute lymphoblastic leukemia (ALL), the most common type of leukemia in children. In this study we compared mitochondrial sequence variation in the D-loop region and in 5 genes of mtDNA in bone marrow samples of 6 pediatric patients with ALL at various stages of therapy. We found several common polymorphisms and one variant at position 3688 whose level varied during leukemia treatment. Our results suggest that mitochondrial DNA mutations, whose levels change during patient treatment, could be potential biomarkers for monitoring treatment efficacy and disease progression.

Keywords

EN

pediatric ALL; mtDNA; chemotherapy

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2017
• Volume: 64
• Issue: 1
• Pages: 183-187

Dates

published

2017

received

2016-10-20

revised

2016-11-11

accepted

2016-12-06

(unknown)

2017-03-09

Contributors

author

Agata Kodroń

• Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland

author

Magda Ghanim

• Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland

author

Katarzyna Krawczyk

• Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland

author

Anna Stelmaszczyk-Emmel

• Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland

author

Katarzyna Tońska

• Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland

author

Urszula Demkow

• Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland

author

Ewa Bartnik

• Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland
• Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

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Identifiers

DOI

10.18388/abp.2016_1444