Hepatic expression of miR-122 and antioxidant genes in patients with chronic hepatitis B

• Authors: Kamila Wójcik , Anna Piekarska , Bożena Szymańska , Elżbieta Jabłonowska
• Languages of publication: EN

Abstracts

EN

Introduction: The pathogenesis of chronic hepatitis B depends on both, the immune response and oxidative stress. Aim of the study: To assess the hepatic expression of miR-122 and the antioxidant genes: HMOX-1, NQO1 and GFER1, in liver biopsy specimens obtained from patients with chronic hepatitis B, with regard to selected clinical and histological parameters, using RT-PCR. Results: The study group comprised 34 HBV-infected patients. Statistically significant associations were found between lower hepatic expression of HMOX-1 and greater severity of liver inflammation (p=0.04). However, significantly higher expression of NQO1 was observed in patients with advanced liver fibrosis (p=0.035). Hepatic expression of miR-122 in HBV patients was not associated with viral load or liver injury. Conclusion: The hepatic expression of HMOX-1and NQO1 may be associated with liver injuries in chronic hepatitis B. However, hepatic expression of miR-122 does not seem to correspond to progression of the liver disease.

Keywords

EN

hepatitis B; antioxidant genes; miR-122

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2016
• Volume: 63
• Issue: 3
• Pages: 527-531

Dates

published

2016

received

2015-11-24

revised

2016-04-20

accepted

2016-05-18

(unknown)

2016-07-08

Contributors

author

Kamila Wójcik

• Department of Infectious Diseases and Hepatology, Medical University of Lodz, Łódź, Poland

author

Anna Piekarska

• Department of Infectious Diseases and Hepatology, Medical University of Lodz, Łódź, Poland

author

Bożena Szymańska

• Central Laboratory, Medical University of Lodz, Łódź, Poland

author

Elżbieta Jabłonowska

• Department of Infectious Diseases and Hepatology, Medical University of Lodz, Łódź, Poland

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Identifiers

DOI

10.18388/abp.2015_1216