The genetic polymorphism in the STK11 does not affect gestational diabetes

• Authors: Khalid Alharbi , Imran Khan , Malek Eldesouky , Malak Al-Hakeem , Zeinab Abotalib
• Languages of publication: EN

Abstracts

EN

Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance of variable severity that develops during pregnancy. Recent studies indicate that GDM onset is rapid, and that women with GDM will develop other metabolic disorders such as obesity, type 2 diabetes, and cardiovascular disease in their future. Serine/threonine kinase 11 (STK11) is engaged in the insulin signaling pathway and encoded protein is an important activator of adenosine monophosphate activated protein kinase. Based on the previously reported association between the STK11 gene and diabetes, we aimed to investigate whether the rs8111699 polymorphism in STK11 has any role in gestation diabetes in Saudi women. In this case-control study, we recruited pregnant Saudi women based on biochemical analysis of their blood samples. Genomic DNA was obtained from confirmed subjects (200 GDM cases and 300 non-GDM). PCR-RFLP analysis was performed to detect the C528G polymorphism in the STK11 gene. The anthropometric and clinical data were similar between the GDM and non-GDM subjects (p > 0.05), whereas the biochemical analysis was significantly different between the cases and controls (p < 0.05). The genotype and allele frequencies between of the STK11 gene were not statistically significant difference between the GDM and non-GDM groups (OR=0.82; 95% CI:=0.6-1.0; p=0.12). Our study suggests that the rs8111699 polymorphism has no role in the development of GDM in pregnant Saudi women.

Keywords

EN

gestational diabetes; STK11; rs8111699 polymorphism; Saudi women

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2015
• Volume: 62
• Issue: 3
• Pages: 569-572

Dates

published

2015

received

2015-04-12

revised

2015-05-04

accepted

2015-07-31

(unknown)

2015-09-08

Contributors

author

Khalid Alharbi

• Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh-11433, Kingdom of Saudi Arabia

author

Imran Khan

• Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh-11433, Kingdom of Saudi Arabia

author

Malek Eldesouky

• College of Dentistry, King Saud University, Riyadh-11545, Kingdom of Saudi Arabia

author

Malak Al-Hakeem

• Department of Obstetrics and Gynecology, College of Medicine, King Khalid University Hospital, Riyadh-11555, Kingdom of Saudi Arabia

author

Zeinab Abotalib

• Department of Obstetrics and Gynecology, College of Medicine, King Khalid University Hospital, Riyadh-11555, Kingdom of Saudi Arabia

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Identifiers

DOI

10.18388/abp.2015_1025