Leonurus cardiaca L. herb - a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis

• Authors: Bartłomiej Micota , Beata Sadowska , Anna Podsędek , Małgorzata Redzynia , Barbara Różalska
• Languages of publication: EN

Abstracts

EN

The objective was an assessment of the impact of Leonurus cardiaca L. extract (LCE) and ursolic acid (UA) on the adhesive properties of Staphylococus aureus NCTC 8325 strain, expressing virulence factors important in the pathogenesis of infective endocarditis. The adhesion and biofilm formation of bacteria cultured in the presence of subinhibitory concentrations of LCE or UA on the abiotic surface or covered with fibrinogen, fibronectin or collagen, were evaluated. Inhibitory effects of LCE and UA on staphylococcal adherence to both types of surface were demonstrated. This, in the case of UA, resulted in a significant reduction of biofilm formation.

Keywords

EN

ECM; Leonurus cardiaca; ursolic acid; Staphylococcus aureus

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2014
• Volume: 61
• Issue: 2
• Pages: 385-388

Dates

published

2014

received

2013-10-28

revised

2014-03-11

accepted

2014-03-27

(unknown)

2014-06-11

Contributors

author

Bartłomiej Micota

• Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Łódź, Poland

author

Beata Sadowska

• Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Łódź, Poland

author

Anna Podsędek

• Institute of Technical Biochemistry, Department of Biotechnology and Food Sciences Lodz Technical University, Poland, Łódź, Poland

author

Małgorzata Redzynia

• Institute of Technical Biochemistry, Department of Biotechnology and Food Sciences Lodz Technical University, Poland, Łódź, Poland

author

Barbara Różalska

• Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Łódź, Poland

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