Ischemia-modified albumin (IMA) is increased in patients with chronic hepatitis C infection and related to markers of oxidative stress and inflammation

• Authors: Jolanta Zuwała-Jagiełło , Maria Warwas , Monika Pazgan-Simon
• Languages of publication: EN

Abstracts

EN

Inflammation and oxidative stress have been reported in patients with chronic hepatitis C (CHC) infection, but their influence on ischemia-modified albumin (IMA) levels and diabetes prevalence remains unknown. Sixty-three CHC patients, 28 with diabetes, and 40 healthy controls were enrolled in the study. Circulating levels of oxidative stress markers [Nε-(carboxymethyl)lysine- advanced glycation end products (CML-AGEs) and advanced oxidation protein products-(AOPPs)], pro-inflammatory cytokines (interleukin-6, and tumor necrosis factor α), and high-sensitivity C-reactive protein (hsCRP) were assessed. Compared with the controls, the CHC patients with diabetes showed a significant increase in plasma concentrations of IMA, AOPPs, interleukin-6 and hsCRP (P < 0.05). The values of IMA and hsCRP were more elevated in patients with diabetes than without diabetes (both P < 0.01). The positive relationships were found between hsCRP and presence of diabetes, IMA (both P < 0.01) and AOPP levels (P < 0.05). CML-AGEs did not show any significant correlation with IMA, markers of inflammation and presence of diabetes. In conclusion, we have documented significant elevation in plasma levels of IMA and AOPPs in CHC patients. In addition, circulating IMA was associated with inflammation markers and diabetes prevalence. This observation suggests a relationship between IMA and inflammation in CHC patients with diabetes, which may represent one of the mechanisms involved in the accelerated atherosclerosis in this population.

Keywords

EN

inflammation; Ischemia-modified albumin; diabetes; HCV infection; oxidative stress

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2012
• Volume: 59
• Issue: 4
• Pages: 661-667

Dates

published

2012

received

2012-07-17

revised

2012-11-07

accepted

2012-11-27

(unknown)

2012-12-06

Contributors

author

Jolanta Zuwała-Jagiełło

• Department of Pharmaceutical Biochemistry, Wrocław Medical University, Wrocław, Poland

author

Maria Warwas

• Department of Pharmaceutical Biochemistry, Wrocław Medical University, Wrocław, Poland

author

Monika Pazgan-Simon

• Clinic of Infectious Diseases, Liver Diseases and Acquired Immune Deficiency, Wrocław Medical University, Wrocław, Poland

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