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2012 | 59 | 4 | 543-547

Article title

Biased versus unbiased randomness in homo-polymers and copolymers of amino acids in the prebiotic world

Content

Title variants

Languages of publication

EN

Abstracts

EN
The polymerization of amino acids under anhydrous prebiotic conditions was first studied several decades ago. Here we use a stochastic model stressing the relevant role of the polarity of amino acids in the formation of oligopeptides in a prebiotic milieu. Our goal is to outline the predominance of co-polypeptides over homo-polypeptides, resulting not only from the randomness, but also from polarity properties of amino acids. Our results conclude that there was a higher probability of the formation of co-polypeptides than of homo-polymers. Besides, we may hypothesize that the former would have a more ample spectrum of possible chemical functions than homo-polypeptides.

Year

Volume

59

Issue

4

Pages

543-547

Physical description

Dates

published
2012
received
2011-10-17
revised
2012-06-13
accepted
2012-10-15
(unknown)
2012-10-26

Contributors

  • Direccion General de Divulgacion de la Ciencia, Universidad Nacional Autonoma de Mexico, Mexico, Mexico
author
  • Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de México, México, Mexico
author
  • Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de México, México, Mexico
  • Departamento de Matematicas, Facultad de Ciencias, Universidad Nacional Autonoma de México, México, Mexico

References

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  • Dickerson RE, Geis I (1969) The Structure and Action of Proteins pp 16-19. Harper & Row Publishers, New York.
  • Fox SW, Melius P, Nakashima T (1977) N-Terminal pyroglutamyl residues in proteins and thermal peptides. Matsubara H, Yamanaka T, eds. Proc. of the Symp. on Evolution of Protein Molecules, pp 111-120. Japan Scientific Societies Press.
  • Harada K (1959) Thermal homopolymerization of lysine and copolymerization with neutral and acidic amino acids. Bull Chem Soc Japan 32: 1007-1008.
  • Harada K, Fox SW (1965) Characterization of thermal polymers of neutral α-amino acids with dicarboxylic amino acids or lysine. Arch Biochem Biophys 109: 49-56.
  • Harada K, Matsuyama M, Kokufuta E (1978) The aqueous thermal polycondensation of asparagines and isoasparagine and the structure of polyaspartic acid. Polymer Bull 1: 177-180.
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  • Meggy AB (1956) Glycine peptides. Part II. The heat and entropy of formation of the peptide bond in polyglycine. J Chem Soc 1444-1454.
  • Moran PAP (1984) An Introduction to Probability Theory, pp 108-111. Clarendon Press, Oxford.
  • Mosqueira FG, Ramos-Bernal S, Negron-Mendoza A (2000) A simple model of the thermal prebiotic oligomerization of amino acids. BioSystems 57: 67-73.
  • Mosqueira FG, Ramos-Bernal S, Negron-Mendoza A (2002) Biased polymers in the origin of life. Biosystems 65: 99-103.
  • Mosqueira FG, Ramos-Bernal S, Negron-Mendoza A (2008) Prebiotic thermal polymerization of crystals of amino acids via the diketopiperazine reaction. BioSystems 91: 195-200.
  • Munegumi T, Tanikawa N, Mita H, Harada K (1994) Peptide formation by heating aqueous solution containing asparagine. Viva Origino 22: 111-125.
  • Nakashima T, Jungck JR, Fox SW, Lederer E, Das BC (1977) A Test for Randomness in Peptides Isolated from a Thermal Polyamino Acid. Int J Quant Chem Quant Biol Symp 4: 65-72.
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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.bwnjournal-article-abpv59p543kz
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