Identification of a novel protein encoded by third conserved gene within RAG locus

• Authors: Monika Kasztura , Arkadiusz Miazek , Małgorzata Cebrat , Paweł Kisielow
• Languages of publication: EN

Abstracts

EN

Recently, a third evolutionarily conserved gene, NWC, was discovered within the recombination activating gene (RAG) locus, known to contain the RAG1 and RAG2 genes. Here, we identify and characterize the murine endogenous NWC protein which has no homology to any known protein and is ubiquitously expressed. In the cell, the NWC protein which has been suggested to function as a transcriptional repressor, is found in the cytoplasm as well as in the nucleus.

Keywords

EN

RAG locus; lymphocytes; T cells; evolutionarily conserved proteins

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2009
• Volume: 56
• Issue: 1
• Pages: 177-181

Dates

published

2009

received

2009-01-30

revised

2009-03-02

accepted

2009-03-13

(unknown)

2009-03-17

Contributors

author

Monika Kasztura

• Laboratory of Transgenesis and Lymphocyte Biology, Department of Tumor Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland

author

Arkadiusz Miazek

• Laboratory of Transgenesis and Lymphocyte Biology, Department of Tumor Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland

author

Małgorzata Cebrat

• Laboratory of Transgenesis and Lymphocyte Biology, Department of Tumor Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland

author

Paweł Kisielow

• Laboratory of Transgenesis and Lymphocyte Biology, Department of Tumor Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland

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