The CDKN2a common variants: 148 Ala/Thr and 500 C/G in 3' UTR, and their association with clinical course of melanoma

• Authors: Katarzyna Monika Lamperska , Anna Przybyła , Witold Kycler , Andrzej Mackiewicz
• Languages of publication: EN

Abstracts

EN

Changes in CDKN2a gene are known to be linked with sporadic melanoma and hereditary predisposition to this cancer. In the Polish population mutations in the coding region of the CDKN2a gene are rather rare, therefore the attention has been focused on polymorphisms and alterations in uncoding regions such as 3' UTR. The aim of this study was to analyze two common polymorphisms, Ala148Thr and 500 C/G, and correlate them with the clinical course of melanoma. DNA from 285 patients was analyzed and found polymorphisms were correlated with the clinical parameters employing statistical methods. The obtained results allow us to conclude: (i) survival times of 500 C/G carriers vs. cumulating proportion surviving was not statistically significant; (ii) CDKN2a polymorphism 500 C/G correlated with Ala148Thr; (iii) no correlation was observed between the 500 C/G polymorphism and age of diagnosis, localization of primary melanoma and survival time; (iv) we did not find correlation between 500 C/G and type of cancer in the family; (v) changes in the CDKN2a gene were not found in patients with second cancer.

Keywords

EN

melanoma; statistical analysis; CDKN2a polymorphisms; 3' UTR

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2007
• Volume: 54
• Issue: 1
• Pages: 119-124

Dates

published

2007

received

2006-10-09

revised

2006-12-18

accepted

2007-02-08

(unknown)

2007-03-09

Contributors

author

Katarzyna Monika Lamperska

• Department of Cancer Diagnostics and Immunology, Wielkopolska Cancer Center, Poznań, Poland

author

Anna Przybyła

• Department of Cancer Immunology, Chair of Medical Biotechnology, University of Medical Sciences, Poznań, Poland

author

Witold Kycler

• The 2nd Department of Oncological Surgery, Wielkopolska Cancer Center, Poznań, Poland

author

Andrzej Mackiewicz

• Department of Cancer Diagnostics and Immunology, Wielkopolska Cancer Center, Poznań, Poland

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