Methylxanthines (caffeine, pentoxifylline and theophylline) decrease the mutagenic effect of daunomycin, doxorubicin and mitoxantrone

• Authors: Jacek Piosik , Anna Gwizdek-Wiśniewska , Katarzyna Ulanowska , Jakub Ochociński , Agata Czyż , Grzegorz Węgrzyn
• Languages of publication: EN

Abstracts

EN

Previously performed experiments showed that methylxanthines, especially caffeine, may protect cells against cytostatic or cytotoxic effects of several aromatic compounds. One of the proposed mechanisms of this protection is based on stacking interactions between π electron systems of polycyclic aromatic molecules. In this work, we demonstrate that caffeine and other methylxanthines - pentoxifylline and theophylline - significantly decrease mutagenicity of the anticancer aromatic drugs daunomycin, doxorubicin and mitoxantrone. The spectrophotometric titration of these aromatic compounds by methylxanthines indicated formation of mixed aggregates. The concentrations of free active forms of the drugs decreased when the concentrations of methylxanthines increased in the mixture. Therefore, likely methylxanthines may play a role of scavengers of the free active forms of daunomycin, doxorubicin and mitoxantrone.

Keywords

EN

Vibrio harveyi mutagenicity assay; mitoxantrone; doxorubicin; daunomycin; xanthines

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2005
• Volume: 52
• Issue: 4
• Pages: 923-926

Dates

published

2005

received

2005-02-15

revised

2005-06-08

accepted

2005-06-24

(unknown)

2005-07-11

Contributors

author

Jacek Piosik

• Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland

author

Anna Gwizdek-Wiśniewska

• Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, Gdańsk, Poland

author

Katarzyna Ulanowska

• Department of Molecular Biology, University of Gdańsk, Gdańsk, Poland

author

Jakub Ochociński

• Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland

author

Agata Czyż

• Laboratory of Molecular Biology (affiliated with the University of Gdańsk), Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Gdańsk, Poland

author

Grzegorz Węgrzyn

• Institute of Oceanology, Polish Academy of Sciences, Gdynia, Poland

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