Inhibition of tumor growth by interleukin 10 gene transfer in B16(F10) melanoma cells

• Authors: Sylwia Walos , Jarosław Szary , Stanisław Szala
• Languages of publication: EN

Abstracts

EN

Interleukin 10 (IL-10) is a potent immunosuppressive cytokine with an antitumor activity. The effect of IL-10 on tumor growth was tested in murine melanoma cells manipulated by gene transfer to secrete IL-10. In mice bearing B16(F10) tumors expressing IL-10  tumor growth was decreased depending on the amount of secreted IL-10.

Keywords

EN

B16(F10) murine melanoma; antiangiogenic effect; interleukin 10

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 1999
• Volume: 46
• Issue: 4
• Pages: 967-970

Dates

published

1999

received

1999-10-14

Contributors

author

Sylwia Walos

• Department of Molecular Biology, Center of Oncology-Maria Skłodowska-Curie Memorial Institute, Wybrzeże Armii Krajowej 15, 44-101 Gliwice, Poland

author

Jarosław Szary

• Department of Molecular Biology, Center of Oncology-Maria Skłodowska-Curie Memorial Institute, Wybrzeże Armii Krajowej 15, 44-101 Gliwice, Poland

author

Stanisław Szala

• Department of Molecular Biology, Center of Oncology-Maria Skłodowska-Curie Memorial Institute, Wybrzeże Armii Krajowej 15, 44-101 Gliwice, Poland