Effects of Growth Hormone Therapy and Physical Exercise on Anaerobic and Aerobic Power, Body Composition, Lipoprotein Profile in Middle Aged Men

• Authors: Adam Zajâc , Miłosz Czuba , Stanisław Poprzecki , Zbigniew Waśkiewicz , Jarosław Cholewa , Jan Pilch , Jakub Chycki
• Languages of publication: EN

Abstracts

EN

Recently growth hormone therapy has been used as an age delaying drug in middle aged men and women as well as in the elderly. Positive effects have been shown in regards to body mass and body composition changes, fat metabolism, bone mineral density and muscle strength. Exercise is a potent physiological stimulus for growth hormone secretion and both aerobic and resistance exercise results in significant, acute serum increases in GH concentration. It is unclear however whether a combination of exercise and hGH therapy further increases physical performance in adults and increases changes in body composition and biochemical variables related to health. For this purpose a group of 15 middle aged men (45,7±5,8 years, 93,2±16,3kg and 183,3±4cm), slightly overweight were randomly divided into an experimental and control groups. Both groups exercised for 3 month, performing 2 aerobic sessions per week and 2 resistance workouts, increasing training loads every two weeks. The experimental group received additionally hGH subcutaneous injections beginning with 0,2 IU daily for the first month and then increasing it to 0,4 and 0,6 IU in successive month. VO2max was evaluated during a progressive ergocycle test to volitional exhaustion, while anaerobic power and capacity were measured during the 30s Wingate test. Additionally body mass and body composition were evaluated as well as the lipoprotein profile and the concentration of chosen anabolic hormones. The results indicate a significant rise in resting concentrations of GH and IGF-1 after the replacement therapy but no additional benefits in regards to aerobic fitness and fat metabolism in comparison to exercise only. A more profound effect was observed in case of anaerobic performance, thus it was concluded that even small doses of hGH stimulated additional protein synthesis following resistance exercise what allowed for significant increases in FFM, anaerobic power (W/kg) and capacity (J/kg) as evaluated obtained during the Wingate test. It was concluded that for a more significant effect of hGH therapy in regards to physical performance greater doses of this hormone have to be used, along with an intensive exercise program.

Keywords

EN

growth hormone; physical performance; body composition; lipoprotein profile

• Publisher: De Gruyter Open
• Journal: Journal of Human Kinetics
• Year: 2010
• Volume: 25
• Pages: 67-76

Dates

published

30 - 9 - 2010

online

9 - 10 - 2010

Contributors

author

Adam Zajâc

• Department of Sports Theory, Academy of Physical Education in Katowice, Poland

author

Miłosz Czuba

• Department of Sports Theory, Academy of Physical Education in Katowice, Poland

author

Stanisław Poprzecki

• Department of Biochemistry, Academy of Physical Education in Katowice, Poland

author

Zbigniew Waśkiewicz

• Department of Sports Games, Academy of Physical Education in Katowice, Poland

author

Jarosław Cholewa

• Department of Sports Theory, Academy of Physical Education in Katowice, Poland

author

Jan Pilch

• Department of Physiological and Medical Sci, Academy of Physical Education in Katowice, Poland

author

Jakub Chycki

• Department of Sports Theory, Academy of Physical Education in Katowice, Poland

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Identifiers

DOI

10.2478/v10078-010-0033-2