Solute permeation through lipid membrane: Statistical Rate Theory approach

• Authors: W. Piasecki , R. Charmas
• Languages of publication: EN

Abstracts

EN

A new model describing transport across lipid membrane was developed based on the Statistical Rate Theory (SRT) of interfacial transfer. In our calculations we replaced lipid membrane with well-defined octanol membrane. According to SRT the rate of solute transfer across water/octanol interface depends on the ratio of solute concentration in the both phases and the water/octanol partition coefficient. In the case of thick membranes and thick diffuse layers our model predicts almost linear dependence of flux on concentration gradient. However, for thin membranes and thin diffuse layers flux becomes nonlinear function of concentration gradient, especially for more polar solutes and higher gradients.

• Publisher: Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej
• Journal: Annales Universitatis Mariae Curie-Skłodowska, sectio AA – Chemia
• Year: 2011
• Volume: 66
• Pages: 147-158

Dates

published

1 - 1 - 2011

online

19 - 12 - 2011

Contributors

author

W. Piasecki

• Department of Biochemistry, Faculty of Physical Education and Sport in Biala Podlaska, The Josef Pilsudski University of Physical Education in Warsaw, Poland

author

R. Charmas

• The State College of Computer Science and Business Administration in Łomża, Poland

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Identifiers

DOI

10.2478/v10063-011-0014-x