Relationships between Insulin-Like Growth Factor I and Selected Clinico-Morphological Parameters in Colorectal Cancer Patients

• Authors: Adam Kukliński , Zbigniew Kamocki , Dariusz Cepowicz , Mariusz Gryko , Jolanta Czyżewska , Krystyna Pawlak , Bogusław Kędra
• Languages of publication: EN

Abstracts

EN

Insulin Like Growth Factor (IGF I) as the one of the strongest growth factors which can affect cancers development including colorectal cancer. IGF I induces processes of the cells growth and division. It regulates cells cycle and inhibits apoptosis. There is limited data about correlation between IGF I and staging of the tumor.The aim of the study was estimation of the clinical usefulness of IGF I concentration in the serum of the patients with colorectal cancer.Material and methods. We have examined 125 individuals with colorectal cancer. The age range was 36 to 92 years. They have been operated in the 2nd Departament of The Gastrointestinal Surgery of the Medical University in Białystok. Serum concentration of the IGF I have been estimated using immunoassay ELISA before and after operation. Correlation between serum level of IGF I and clinicopathologic features: age, gender, localisation of the primary tumor, TNM stage of tumor, histological type and histological grade (G) of the cancer have been estimated.Results. Our study revealed statistically significant increased serum concentration of IGF I in patients with locally advanced colorectal cancer (pT3 and pT4) comparing to less advanced (pT2) The investigations showed higher serum concentration of IGF I in patients with poorly differentiated cancers (G3) than in moderately differentiated. Similarly higher serum concentration of IGF I were found in male, in patients older than 60 years and in mucigenous colorectal cancers.Conclusions. Our results indicated that IGF I can be one of the factors of the prognosis in colorectal cancer development.

Keywords

EN

IGF I; colorectal cancer; clinico-morphological parameters; surgery

• Publisher: De Gruyter Open
• Journal: Polish Journal of Surgery
• Year: 2011
• Volume: 83
• Issue: 5
• Pages: 250-257

Dates

published

1 - 5 - 2011

online

24 - 6 - 2011

Contributors

author

Adam Kukliński

• 2nd Department of General and Gastroenteral Surgery, Medical University in Białystok

author

Zbigniew Kamocki

• 2nd Department of General and Gastroenteral Surgery, Medical University in Białystok

author

Dariusz Cepowicz

• 2nd Department of General and Gastroenteral Surgery, Medical University in Białystok

author

Mariusz Gryko

• 2nd Department of General and Gastroenteral Surgery, Medical University in Białystok

author

Jolanta Czyżewska

• Department of Clinical Laboratory Diagnostics, Medical University in Białystok

author

Krystyna Pawlak

• Department of Nephrology and Transplantology with Dialysis Unit, Medical University in Białystok

author

Bogusław Kędra

• 2nd Department of General and Gastroenteral Surgery, Medical University in Białystok

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Identifiers

DOI

10.2478/v10035-011-0039-z