Influence of Donor and Recipient Gender as well as Selected Factors on the Five-Year Survival of Kidney Graft

• Authors: Maciej Głyda , Wojciech Czapiewski , Marek Karczewski , Renata Pięta , Andrzej Oko
• Languages of publication: EN

Abstracts

EN

The aim of the study was to determine the impact of the gender of renal allograft donor and recipient on the graft function over a 5-year follow-up period.Material and methods. The 154 kidney grafts from 77 donors transplanted into recipients of both genders. Two study groups were formed: one group consisted of male donors, while the other consisted of female donors. The recipients in each of the groups consisted of a pair, one male and one female.Results. 71% of grafts survived the five-year period in the group of male and female recipients when the donor was male; in case of female donors, the rate was 62.5%. Depending on the gender of the donor and the recipient, the rates of grafts with five-year survival were as follows: 79.2% for male donors and female recipients (MF); 62.5% for male donors and male recipients (MM). The difference between both groups was not statistically significant. In the case of female donors and male recipients (FM), the five-year survival rate was 58.3%, while in female donors and female recipients, the five-year survival rate was 64.1%.Conclusions. Grafts from male donors show a trend towards better five-year survival compared to grafts from female donors. The highest five-year survival rate was observed when the donor was male and the recipient was female; the lowest rate was observed for female donors and male recipients.

Keywords

EN

kidney transplantation; donor; recipient gender

• Publisher: De Gruyter Open
• Journal: Polish Journal of Surgery
• Year: 2011
• Volume: 83
• Issue: 4
• Pages: 188-195

Dates

published

1 - 4 - 2011

online

7 - 6 - 2011

Contributors

author

Maciej Głyda

• Department of Transplantology and Surgery, Provincial Hospital in Poznań

author

Wojciech Czapiewski

• Department of Transplantology and Surgery, Provincial Hospital in Poznań

author

Marek Karczewski

• Department of Transplantology and Surgery, Provincial Hospital in Poznań

author

Renata Pięta

• Department of Transplantology and Surgery, Provincial Hospital in Poznań

author

Andrzej Oko

• Chair and Department of Nephrology, Transplantology and Internal Diseases in Poznań

References

• BasarH, Soran A, Shapiro R: Renal transplanatation in recipients over the age of 60: the impact of donor age. Transplantation 1999; 67(8): 1191-93.[Crossref]
• Benoit G, N'Doye P, Busson M: Analysis of cadaver donor criteria on the kidney transpant survival rate in 5,129 transplantations. J Urol 1995; 154(2-1): 356-60.
• Bertoni E, Zanazzi M, Rosati A: Fate of kindeys from the same donor grafted into different recipients: do They behave similarly and are they influenced by donor-related factors? J Nephrology 2000; 13(2): 150-54.
• Blagojevia-Lazia R. Radivojevia D: Results of kidney transplantation at the Institute of Urology and Nephrology of the Serbian Clinical ter in Belgrade. SRPSKI ARHIV Za Celoko Lekarstvo Serbian Archives of Entire Medicine: Archives Serbes de Medicine Generale, 2000; 128(5-6): 149-56.
• Bohatyrewicz. R: Rozprawa habilitacyjna. Anestezjologia, Intensywna Terapia 1/99 suplement.
• Brenner B, Mackenzie H: Nephron endowment and the pathogenesis of chronic renal failure. Kluwer Academic Publishers, Late Graft Loss 1997; 93-100.
• Chen CH, Shu KH, Yang CR: Long-Term Results with Pediatric Kidney Transplants in Adult Recipients. J Formosan Med Associati 1999; 98(12): 807-13.
• Chertow GM, Brenner BM, Mackenzie HS: Non-immunologic predictors of chronic renal allograft failure: data from the United Network of Organ Sharing. Kidney International-Suplement, 1995; 52(): 48-51.
• Chertow Glenn M, Milford Edgar L, Mackenzie Harald L et al.: Antigen-independent determinants of cadaveric kidney transplant failure. JAMA 1996; 276(21): 1732-36.
• Długosz R: Evaluation of factros affecting early and late outcome of 225 kidney Transplantations. Ann Acad Midicae Stetinensis 1999; 45: 93-107.
• Frei U, Schindler R, Wieters D, Grouven U: Pretransplant hypertention: a major risk factor chornic progressive renal allograft dysfunction? Nephrol Dialysis Transplant 1995; 10(7): 1206-11.
• Gjertson DW: A multi-factor analysis of kidney graft outcomes at one and five years posttransplantation. Clinical Transplants 1997; 343-60.
• Holly JL, Shapiro R, Tzakis AG et al.: Obesity as a risk factor following cadaveric renal transplantation. Transplantation 1990; 49: 387-91.[Crossref]
• Jakóbisiak M: Antygeny zgodności tkankowej u ludzi. Przeszczepianie nerek pod red. T Orłowskiego. PZWL, Warszawa 1995.
• Kouli F, Morrell C, Ratner LE et al.: Impact of Donor/Recipient Traits Independent of rejection on Long-Term Renal Function. Am J Kidney Dis 2001; 37(2): 356-65.[Crossref]
• Lee CM, Carter JT, Randall HB: The effect of age and prolonged cold ischemia times an the national allocation of cadaveric renal allografts. J Surg Res 2000; 91(1): 83-88.[Crossref][PubMed]
• Matas AJ, Gillingham KJ, Payne WD: The impact of an acute rejection episode on long-term renal allograft survival (t1/2). Transplantation 1994,; 57(6): 857-61.
• Meier-Kriesche HU, Ojo AO, Hanson JA: Increased impact of acute rejection on chronic allograft failure in recent era. Transplantation 2000; 70(7): 1098-99[Crossref]
• Meier-Krieche HU, Ojo AO, Leavey SF et al.: Gender Differences in the risk for chronik renal allograft failure. Transplantation 2001; 71(3): 429-32[Crossref]
• Mingxi LI, Kathy M. Nicholls, Gavin J. Becker. Risk factors for late renal allograft dysfunction: Effects of baseline glomerular size. J Nephrol 2002; 15: 620-25.
• Modlin C, Goldfarb D, Novick AC: Hyperfiltration nephropathy as a cause of late graft loss in renal transplanation. World J Urol 1997; 14(4): 256-64.
• Muller V, Szabo A, Viklicky O: Sex hormones and gender-related differences: Their influence on chronic renal allograft rejection. Kidney International-Suplement, 1999; 55(5): 2011-20.[Crossref][PubMed]
• Zeier M, Dalhler B, Opelz G, Ritz E: The effect of donor gender an graft survival. J Am Society of Nephrol 2002; 13(10): 2570-76.[Crossref]
• Vereerstraeten P, Wissing M, De Pauw L et al.: Male recipients of kidneys from female donors are at increased risk of graft lose from borh rejection and technical failure. Clinical Transplants 1999; 13(2): 181-86.
• Valdes F, Pita S, Alonso A, Rivera CF et al.: The effect of donor gender on renal allograft survival and influence of donor age on posttransplant graft outcome and patient survival. Transplantation Proceedings 1998; 29(8): 3371-72.
• Yamamoto, Shinji, Hanley, Eileen, Hahn, Amy B, Isenberg et al.: The impact of obesity in renal transplantation: an anlysis of paired cadaver kidneys. Clinical Transplantation 2002, 16 (4): 252-56.[Crossref]

Identifiers

DOI

10.2478/v10035-011-0029-1