Melatonin protection against burn-induced liver injury. A review

• Authors: Ganka Bekyarova , Maria Tzaneva , Minka Hristova , Krasimir Hristov
• Languages of publication: EN

Abstracts

EN

Severe thermal injury may be complicated by dysfunction of organs distant from the original burn wound, including the liver, and represents a serious clinical problem. Although pathophysiology of burn-induced liver injury remains unclear, increasing evidence implicate activation of inflammatory response, oxidative stress, endothelial dysfunction and microcirculatory disorders as the main mechanisms of hepatic injury. Several studies suggest melatonin as a multifunctional indolamine that counteracts some of the pathophysiologic steps and displays significant beneficial effects against burn-induced cellular injury. This review summarizes the role of melatonin in restricting the burn-induced hepatic injury and focuses on its effects on oxidative stress, inflammatory response, endothelial dysfunction and microcirculatory disorders as well as on signaling pathways such as regulation of nuclear erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappaB (NF-kB). Further studies are necessary to elucidate the modulating effect of melatonin on the transcription factor responsible for the regulation of the pro-inflammatory and antioxidant genes involved in burn injuries.

Keywords

EN

Melatonin; Liver injury; Oxidative stress; Inflamamation; Endothelial dysfunction; Microcirculatory disorders; Burns

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2014
• Volume: 9
• Issue: 1
• Pages: 148-158

Dates

published

1 - 2 - 2014

online

4 - 2 - 2014

Contributors

author

Ganka Bekyarova

• Division of Pathophysiology, Medical University, Varna, Bulgaria

author

Maria Tzaneva

• Department of General and Clinical Pathology, Medical University-Varna, Varna, Bulgaria

author

Minka Hristova

• Division of Pathophysiology, Medical University, Varna, Bulgaria

author

Krasimir Hristov

• Division of Pathophysiology, Medical University, Varna, Bulgaria

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Identifiers

DOI

10.2478/s11536-013-0253-7