Ischemic and non-ischemic dilated cardiomyopathy

• Authors: Giovanni Fazio , Federica Vernuccio , Emanuele Grassedonio , Giuseppe Grutta , Giuseppe Lo Re , Massimo Midiri
• Languages of publication: EN

Abstracts

EN

Dilated Cardiomyopathy is a high-incident disease, which diagnosis of and treatments are clinical priority. The aim of our study was to evaluate the diagnostic potential of cardiac magnetic resonance (CMR) imaging; echocardiography and the biochemical parameters that can help us differentiate between the post-ischemic and non-ischemic dilated cardiomyopathy. Materials and methods. The study enrolled 134 patients with dilated cardiomyopathy: 74 with the post-ischemic form and 60 with the non-ischemic one. All patients underwent a coronary imaging test, with echocardiogram, cardiac magnetic resonance and a blood test. Pro-inflammatory cytokines were evaluated using Luminex kit. Data was compared between the two groups. Results. Echocardiography allowed recognition of Left Ventricular Non Compaction in 2 patients. Longitudinal and circumferential strains were significantly different in the two groups (p<0.05). Using CMR imaging a post-myocarditis scar was diagnosed in 2 patients and a post-ischemic scar in 95% of patients with the chronic ischemic disease. The interleukin IL-1, IL-6 and TNF-α levels were higher in the post-ischemic group compared with the non-ischemic one. Conclusions. The use of second level techniques with a high sensitivity and specificity would help distinguish among different sub-forms of dilated cardiomyopathy.

Keywords

EN

Dilated cardiomyopathy; Cardiac magnetic resonance

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2014
• Volume: 9
• Issue: 1
• Pages: 15-20

Dates

published

1 - 2 - 2014

online

4 - 2 - 2014

Contributors

author

Giovanni Fazio

• Medical Clinic Riabiliter S.N.C., Via Oreto, 340, 90124, Palermo, Sicilia, Italy

author

Federica Vernuccio

• Department of Radiology, University of Palermo, Palermo, Italy

author

Emanuele Grassedonio

• Department of Radiology, University of Palermo, Palermo, Italy

author

Giuseppe Grutta

• Medical Clinic Riabiliter S.N.C., Via Oreto, 340, 90124, Palermo, Sicilia, Italy

author

Giuseppe Lo Re

• Department of Radiology, University of Palermo, Palermo, Italy

author

Massimo Midiri

• Department of Radiology, University of Palermo, Palermo, Italy

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Identifiers

DOI

10.2478/s11536-013-0233-y