Intervention for cardiovascular risk factors decreases adipocyte fatty acid-binding protein levels in males - a pilot study

• Authors: Eliska Sovova , Marketa Kaletova , David Stejskal , Milan Kaminek , Marie Budikova , Iva Metelkova , Dagmar Horakova , Milan Sova , Marketa Sovova , Jindrichv Palcik , Jana Zapletalova
• Languages of publication: EN

Abstracts

EN

Cardiovascular disease (CVD) remains the leading cause of mortality in developed countries. According to the 2012 European Guidelines on Cardiovascular Disease Prevention in Clinical Practice, family history is a cornerstone for risk stratification of CVD. First-degree relatives are persons in whom CVD should be assessed and targeted intervention should be performed. The aims of this pilot study were (i) to determine risk factors (RFs) for cardiovascular disease (CVD) in a group of first-degree relatives of patients with CVD at baseline and after 1 year, (ii) to measure adipocyte fatty acid-binding protein (A-FABP) levels as a potential connecting link between metabolic disease and atherosclerosis, and (iii) to determine the impact of targeted intervention on these parameters. The study comprised 62 asymptomatic subjects (41 males; mean age of 53.8±8.3 years). Preventive examinations and interventions were carried out at baseline and at 1-year follow-up to assess RFs and evaluate A-FABP levels. At 1 year, males had significantly lower levels of cholesterol (median 5.18 vs 4.67, p=0.005), HDL (median 1.24 vs 1.14, p=0.021), LDL (median 3.08 vs 2.46, p=0.021), ApoB (median 0.99 vs 0.82, p=0.012) and A-FABP (median 19.84 vs 16.73, p = 0.015). In females after 1 year, only significantly lower levels of fibrinogen (median 3.10 vs 2.79, p=0.043) were found. All subjects were clinically examined or contacted by phone after a mean of 36.7 months (range, 11–55). Over that time, no serious complications were noted. In males, intervention for RFs leads to lower levels of A-FABP as a potential RF linking metabolic syndrome to atherosclerosis.

Keywords

EN

Adipocyte fatty acid-binding protein; Prevention; Cardiovascular disease; Relatives

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2014
• Volume: 9
• Issue: 1
• Pages: 28-33

Dates

published

1 - 2 - 2014

online

4 - 2 - 2014

Contributors

author

Eliska Sovova

• Palacky University Olomouc, Czech Republic, Olomouc, 779 00, tr. Svobody 8

author

Marketa Kaletova

• Palacky University Olomouc, Czech Republic, Olomouc, 779 00, tr. Svobody 8

author

David Stejskal

• Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic, Olomouc, 779 00, tr. Svobody 8

author

Milan Kaminek

• Department of Nuclear Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic, Olomouc, 779 00, tr. Svobody 8

author

Marie Budikova

• Department of Nuclear Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic, Olomouc, 779 00, tr. Svobody 8

author

Iva Metelkova

• Department of Nuclear Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic, Olomouc, 779 00, tr. Svobody 8

author

Dagmar Horakova

• Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic, Olomouc, 779 00, tr. Svobody 8

author

Milan Sova

• Department of Respiratory Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic, Olomouc, 779 00, tr. Svobody 8

author

Marketa Sovova

• Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic, Olomouc, 779 00, tr. Svobody 8

author

Jindrichv Palcik

• Department of Exercise Medicine and Cardiovascular Rehabilitation, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic, Olomouc, 779 00, tr. Svobody 8

author

Jana Zapletalova

• Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic, Olomouc, 779 00, tr. Svobody 8

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Identifiers

DOI

10.2478/s11536-013-0231-0