The possible protective mechanism of Hyperbaric oxygen (HBO) in memory impairments induced by Aβ25–35 in rats

• Authors: XiaoQiang Tian , LiDa Zhang , JingMei Wang , JianGuo Dai , ShanShan Shen , Lin Yang , PeiLin Huang
• Languages of publication: EN

Abstracts

EN

Alzheimer’s disease is characterized by the accumulation and deposition of Aβ peptides in human brains. Aβ peptides are toxic to neurons by lots of mechanisms of which Aβ induced oxidative stress is one of the hypothesis. The present study aimed to determine the effect of Hyperbaric oxygen (HBO) on Aβ25–35 induced cognitive deficits and oxidative stress and apoptosis effects in rats. Rats were given an injection of aggregated Aβ25–35. After treatment with HBO for 20days, the learning and memory ability, hippocampus neuronal apoptosis, the activity of SOD, GSH content and the MDA level and mRNA and proteins expression of Bcl-2 and Bax were detected. Our results demonstrated that HBO could significantly improved the apoptosis hippocampus neuronal induced by Aβ25–35, involving the improvement of the learning and memory impairment, which accompanied of increasing the gene and protein expression of bcl-2 and enhancing the activity of SOD and GSH content. These findings suggest that treatment of HBO might prevent the Aβ25–35 induced learning and memory impairment by increasing the gene and protein expression of bcl-2 and enhancing the activity of SOD and GSH content to alleviate the apoptosis hippocampus neuronal. This suggests that HBO may be a potential therapeutic agent for AD.

Keywords

EN

Alzheimer’s disease (AD); Hyperbaric oxygen (HBO); Neuroprotective; Aβ25–35

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2013
• Volume: 8
• Issue: 4
• Pages: 468-475

Dates

published

1 - 8 - 2013

online

12 - 6 - 2013

Contributors

author

XiaoQiang Tian

• School of Medicine, Southeast University, Nanjing, China

author

LiDa Zhang

• Affiliated Zhongda Hospital of Southeast University, Nanjing, China

author

JingMei Wang

• Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

author

JianGuo Dai

• Department of Pathology, Nanjing University of Traditional Chinese Medicine, Nanjing, China

author

ShanShan Shen

• Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

author

Lin Yang

• School of Medicine, Southeast University, Nanjing, China

author

PeiLin Huang

• School of Medicine, Southeast University, Nanjing, China

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Identifiers

DOI

10.2478/s11536-013-0163-8