Asymptomatic carriers of clostridium difficile in serbian population

• Authors: Predrag Stojanović , Nevena Stojanović , Branislava Kocic , Dobrila Stanković-Đorđević , Tatjana Babić , Kristina Stojanović
• Languages of publication: EN

Abstracts

EN

The aim of the research was to determine the intestinal carriers of C. difficile in different human population groups in Serbia. The research enrolled 877 persons with formed stools: (newborn children in maternity hospitals for up to two weeks old) (23), group A; children aged from two weeks to two years (121), group B; children aged two to 10 years (54), group C, healthy individuals aged 10 and over (516), group D; patients hospitalized for at least 48 hours (100), group E; staff of the Clinical Center in Nis, Serbia, (63), group F. The toxins A and B of C. difficile were detected by ELISA-ridascreen Clostridium difficile Toxin A/B (R - Biopharm AG, Darmstadt, Germany). The toxin A of C. difficile was detected using ColorPAC Toxin A test (BectonDickinson, New Jersey, USA). Out of the total number of persons (877), the carriers of certain types of toxin-producing strains of C. difficile were distributed as: 6.04% (A−/B−), 1.83% (A+/B+) and 0.11% (A−/B+). In most groups (5/6), the dominance of non-toxigenic (A−/B−) isolates was established, with the rate of carriers 1.75 – 30.43% depending on the group. Toxigenic isolates were prevalent only in the group F in relation to non - toxigenic (7.94% versus 4.76% of persons). In other groups, the carriers of toxigenic strains ranged from 0.00 – 17.45%. The presence of asymptomatic intestinal carriers of C. difficile in the human population, indicate the possible reservoirs and sources of infection.

Keywords

EN

Clostridium difficile; Asymptomatic intestinal carriers; Children; Hospitalized patients; Medical staff

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2012
• Volume: 7
• Issue: 6
• Pages: 769-774

Dates

published

1 - 12 - 2012

online

11 - 10 - 2012

Contributors

author

Predrag Stojanović

author

Nevena Stojanović

• Gynecology — Obstetrics Clinic (Department of Neonatology), 18000, Nis, Serbia

author

Branislava Kocic

author

Dobrila Stanković-Đorđević

author

Tatjana Babić

• Institute for Public Health Nis, Center of Microbiology, 18000, Nis, Serbia

author

Kristina Stojanović

• Clinical Centar, 18000, Nis, Serbia

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Identifiers

DOI

10.2478/s11536-012-0067-z