Statistical interpretation of medical data of patients with alcohol abuse

• Authors: Ventzislav Bardarov , Pavlina Simeonova , Ludmila Neikova , Krum Bardarov , Vasil Simeonov , Stefan Tsakovski , Kamen Kanev
• Languages of publication: EN

Abstracts

EN

An attempt is made to assess a set of biochemical, kinetic and anthropometric data for patients suffering from alcohol abuse (alcoholics) and healthy patients (non-alcoholics). The main goal is to identify the data set structure, finding groups of similarity among the clinical parameters or among the patients. Multivariate statistical methods (cluster analysis and principal components analysis) were used to assess the data collection. Several significant patterns of related parameters were found to be representative of the role of the liver function, kinetic and anthropometric indicators (conditionally named “liver function factor”, “ethanol metabolism factor”, “body weight factor”, and “acetaldehyde metabolic factor”). An effort is made to connect the role of kinetic parameters for acetaldehyde metabolism with biochemical, ethanol kinetic and anthropometric data in parallel.

Keywords

EN

Chemometrics; Alcohol abuse; Modeling; Clinical data

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2012
• Volume: 7
• Issue: 4
• Pages: 465-474

Dates

published

1 - 8 - 2012

online

24 - 5 - 2012

Contributors

author

Ventzislav Bardarov

• Military Medical Academy, 1606, Sofia, Bulgaria

author

Pavlina Simeonova

• Laboratory of Environmental Physics, Georgi Nadjakov Institute of Solid State Physics, Bulgarian Academy of Sciences, Tzarigradsko Chaussee 72, 1784, Sofia, Bulgaria

author

Ludmila Neikova

• Military Medical Academy, 1606, Sofia, Bulgaria

author

Krum Bardarov

• Chair of Analytical Chemistry, Faculty of Chemistry, University of Sofia “St. Kl. Okhridski”, J. Bourchier Blvd. 1, 1164, Sofia, Bulgaria

author

Vasil Simeonov

• Chair of Analytical Chemistry, Faculty of Chemistry, University of Sofia “St. Kl. Okhridski”, J. Bourchier Blvd. 1, 1164, Sofia, Bulgaria

author

Stefan Tsakovski

• Chair of Analytical Chemistry, Faculty of Chemistry, University of Sofia “St. Kl. Okhridski”, J. Bourchier Blvd. 1, 1164, Sofia, Bulgaria

author

Kamen Kanev

• Military Medical Academy, 1606, Sofia, Bulgaria

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Identifiers

DOI

10.2478/s11536-012-0020-1