Alteration of secretory IgA in human breast milk and stool samples after the intake of a probiotic - report of 2 cases

• Authors: Petar Nikolov , Marta Baleva
• Languages of publication: EN

Abstracts

EN

Only a few studies reveal immunological changes in breast milk after the intake of probiotic and none focus on secretory IgA (sIgA). The aim our report was to investigate the levels of sIgA in human breast milk and stools before and after 4 weeks of probiotic intake in a patient with ulcerative colitis (UC) and a control. The study included 2 lactating women: 1 with UC and 1 control. Both received daily 3.75 billion viable Lactobacillus bulgaricus for 28 days. SIgA was measured in breast milk and stools before and after the probiotic intake. The concentration of sIgA in breast milk before the probiotic intake in UC was 408.5 vs 137.4 µg/ml in contol. Fecal sIgA in UC was 420 vs 274 µg/ml in control. After 28 days of probiotic intake there was a decrease in breast milk sIgA in UC but an increase in control - 266.7 vs 914 µg/ml respectively. There was an increase in fecal sIgA both in UC and control - 674.4 vs 1033 µg/ml. It is tempting to speculate that the different sIgA secretion towards the probiotic may be a result of an altered mucosal immune response in UC.

Keywords

EN

Human breast milk; Secretory IgA; Probiotic; Ulcerative colitis

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2012
• Volume: 7
• Issue: 1
• Pages: 25-29

Dates

published

1 - 2 - 2012

online

24 - 11 - 2011

Contributors

author

Petar Nikolov

• Clinic of Gastroenterology, St. Ivan Rilsky University Hospital, 15 Acad. Ivan Geshov blvd, Sofia, 1431, Bulgaria

author

Marta Baleva

• Clinic of Clinical Immunology, University Hospital Alexandrovska, Sofia, 1431, POBox 45, Bulgaria

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Identifiers

DOI

10.2478/s11536-011-0104-3