Cadmium exposure induced itai-itai-like syndrome in male rats

• Authors: Xiao Chen , Guoying Zhu , Taiyi Jin , Shuzhu Gu , Mingguang Tan , Hanfang Xiao , Jing Qiu
• Languages of publication: EN

Abstracts

EN

Fourteen Sprague-Dawley male rats were randomly divided into 2 groups which were given CdCl2 at the doses of 0 and 1.5 mg /kg for 12 weeks. Before sacrifice, microCT scanning were performed on the proximal tibia and urine were collected for cadmium and N-acetyl-beta-D-glucosaminidase assay, then all of rats were sacrificed and blood was collected for biomarkers measurement; bone tissues were collected for bone mass, histology and biomechanical analysis. The cadmium in blood, urine, bone and kidney of rats treated with cadmium was significantly higher than those in the control group. The bone mineral density, and bone mineral ability of rats treated with cadmium were obviously decreased by 20%–50% compared to controls. Bone microstructure index and trabecular separation of rats treated with cadmium were obviously lower (−50%) and significantly higher (+150%) than that in the control group. Bone biomechanical property decreased by 30%–60% in cadmium treated rats compared to control. Tartrate-resistant acid phosphatase 5b and alkaline phosphatase levels of rats treated with cadmium were significantly higher than those in control, but serum osteocalcin level decreased greatly by cadmium. Obvious proximal tubule damage occurred after cadmium exposure. These observations gave clear and comprehensive evidence that cadmium exposure could induce itai-itai-like syndrome in male rats.

Keywords

EN

Cadmium; Bone microstructure; Tartrate-resistant acid phosphatase 5b; Bone mineral density; Micro-computed tomography; Itai-itai-like syndrome

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2011
• Volume: 6
• Issue: 4
• Pages: 425-434

Dates

published

1 - 8 - 2011

online

1 - 6 - 2011

Contributors

author

Xiao Chen

• Institute of radiation medicine, Fudan University, 200032, Shanghai, China

author

Guoying Zhu

• Institute of radiation medicine, Fudan University, 200032, Shanghai, China

author

Taiyi Jin

• School of public health, Fudan University, 200032, Shanghai, China

author

Shuzhu Gu

• Institute of radiation medicine, Fudan University, 200032, Shanghai, China

author

Mingguang Tan

• Shanghai Institute of Applied physics, Chinese Academy of Sciences, 200032, Shanghai, China

author

Hanfang Xiao

• Institute of radiation medicine, Fudan University, 200032, Shanghai, China

author

Jing Qiu

• Institute of radiation medicine, Fudan University, 200032, Shanghai, China

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Identifiers

DOI

10.2478/s11536-011-0046-9