Sarcomatoid carcinoma of the urinary bladder and concomitant abdominal aortic aneurysm: a case report and literature review

• Authors: Simona Francesco , Salvatore Magnasco , Raffaele Tenaglia
• Languages of publication: EN

Abstracts

EN

We report the diagnostic evaluation, management, and intermediate-term outcomes of a rare variant of bladder cancer and concomitant Abdominal Aortic Aneurysm. A 62 year old male with gross haematuria and Abdominal Aortic Aneurysm was admitted to our hospital. Cystoscopy revealed a large bulky mass occupying the posterior bladder wall. The tumor was transurethrally resected and its histology showed a Sarcomatoid Carcinoma of the urinary bladder. Due to the aggressive behavior of the tumor and the risk of aneurysm rupture, concomitant endovascular exclusion of Aneurysm, total cystectomy with urinary diversion was performed. 12 months after radical surgery the patient was alive without any local recurrence, distant metastasis, and thrombosis of iliac axis. To our knowledge this study is the first report to describe data on the diagnostic evaluation, Management, and intermediate-term outcomes in Sarcomatoid carcinoma and Concomitant Abdominal Aortic Aneurysm. Multi-institutional collaboration is important to perform clinical trials of adequate sample size to design more effective treatments for these aggressive cancers in the presence of Concomitant Abdominal Aortic Aneurysm.

Keywords

EN

Bladder Cancer; Sarcomatoid Carcinoma; Abdominal Aortic Aneurysm; Endoprosthesis

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2011
• Volume: 6
• Issue: 3
• Pages: 284-288

Dates

published

1 - 6 - 2011

online

8 - 4 - 2011

Contributors

author

Simona Francesco

• Department of Medicine and Aging Science, Section of Clinical Urology and Andrology, University “G. D’Annunzio” Chieti-Pescara, Via dei Vestini 5, 66100, Chieti, Italy

author

Salvatore Magnasco

• Department of Pathological Anatomy, University “G. D’Annunzio” Chieti-Pescara, Via dei Vestini 5, 66100, Chieti, Italy

author

Raffaele Tenaglia

• Department of Medicine and Aging Science, Section of Clinical Urology and Andrology, University “G. D’Annunzio” Chieti-Pescara, Via dei Vestini 5, 66100, Chieti, Italy

References

• [1] Dahm P., Gschwend J. E. Malignant Non-Urothelial Neoplasms of the Urinary Bladder: A Review. Eur Urol 2003; 44: 672–681 http://dx.doi.org/10.1016/S0302-2838(03)00416-0[Crossref]
• [2] Torenbeek R., Blomjous C. M., De Bruin P. C., Newling D. W., Meijer C. J.: Sarcomatoid carcinoma of the urinary bladder. Am. J. Surg. Pathol. 1994; 18:241 http://dx.doi.org/10.1097/00000478-199403000-00003[Crossref]
• [3] Lopez-Beltran A., Pacelli A, Rothenberg H. J. et al. Carcinosarcoma and sarcomatoid carcinoma of the bladder: clinicopathological study of 41 Cases. J Urol. 1998; 159:1497–1503 http://dx.doi.org/10.1097/00005392-199805000-00023[Crossref]
• [4] Ikegami H., Iwasaki H., Ohjimi Y., Takeuchi T., Ariyoshi A., Kikuchi M. Sarcomatoid carcinoma of the Urinary Bladder: a clinicopathologic and immunohistochemical analysis of 14 Patients. Hum Pathol 2000; 31:332–340 http://dx.doi.org/10.1016/S0046-8177(00)80247-6[Crossref]
• [5] Antonelli A., Simeone C., Ferrari V., Tardanico R., Cunico Cosciani S. Durable and complete remission of a metastatic bladder sarcomatoid carcinoma with chemotherapic and surgical treatments. Arch. Ital. Urol. Androl. 2006; 78:67–70 [PubMed]
• [6] Lopez-Beltran A., Requena M. J., Cheng L., Montironi R. Pathological variants of invasive bladder cancer according to their suggested clinical significance BJU Int. 2008; 101:275–281 http://dx.doi.org/10.1111/j.1464-410X.2007.07271.x[WoS][Crossref]
• [7] Sung M. T., Wang M., MacLennan G.T. et al. Histogenesis of sarcomatoid urothelial carcinoma of the urinary bladder: evidence for a common clonal origin with divergent differentiation J Pathol. 2007; 211:420–430 http://dx.doi.org/10.1002/path.2129[WoS][Crossref]
• [8] Lopez-Beltran A., Requena M. J., Liang C. and Montironi R. Pathological variants of invasive bladder cancer according to their suggested clinical significance. BJU Int. 2007; 101:275–281 http://dx.doi.org/10.1111/j.1464-410X.2007.07271.x[WoS][Crossref]
• [9] Arenas L. F., Fontes D. A., Pereira E. M., Hering F. L. Sarcomatoid carcinoma with osseous differentiation in the bladder Int. Braz J Urol 2006; 32:563–565 [PubMed]
• [10] Black P. C., Brown G. A., Dinney C. P, The impact of variant histology on the outcome of bladder cancer treated with curative intent. Urol. Oncol 2009; 27:3–7 [WoS]
• [11] Pagano S., Ruggeri P., Franzoso F., Brusamolino R., Unusual renal cell carcinoma metastasis to the gallbladder Urol. 1995; 45:867–869 [PubMed]
• [12] Grego F., Lepidi S., Bassi P. et al. Simultaneous surgical treatment of abdominal aortic aneurysm and carcinoma of the bladder. J Vasc Surg 2003; 37:607–614 http://dx.doi.org/10.1067/mva.2003.26[Crossref]
• [13] Mearini L., Zucchi A., Pizzirusso G., Vivaacqua C., Mearini L. Incidence and evolution of aortic aneurysm in patient with bladder cancer Arch. Ital. Urol. Androl. 2004; 76:80–82

Identifiers

DOI

10.2478/s11536-011-0017-1