Plasma level of myeloperoxidase in children with juvenile idiopathic arthritis (a pilot study)

• Authors: Chris Pruunsild , Kaire Heilman , Kersti Zilmer , Karin Uibo , Hille Liivamägi , Tiina Talvik , Mihkel Zilmer , Vallo Tillmann
• Languages of publication: EN

Abstracts

EN

To examine the plasma levels of MPO in oligoarthritis and polyarthritis subtypes of JIA in comparison with healthy age-matched controls. Thirty-eight JIA patients (25 girls and 13 boys) aged 9.1–11.8 years and 23 healthy controls (8 girls and 15 boys) participated in the study. Twenty-one patients had oligoarthritis (8 with extended oligoarthritis) and 17 had polyarthritis (among them three were seropositive). The plasma concentration of MPO was measured by the ELISA technique (OxisResearchTM, BIOXYTECH® MPO-EIATM, Portland, OR USA). The mean plasma concentration of MPO in the JIA group was significantly higher than in the control group (76.6±24.8 µg/L versus 62.7±15.6 µg/L; p=0.01). Patients with polyarthritis presented a significantly higher mean plasma MPO level than patients with oligoarthritis (81.3±25.6 µg/L and 62.1±27.1 µg/L, respectively; p=0.02). Different subtypes of JIA may have different MPO-related backgrounds. MPO is a new potent inflammatory marker. Patients with polyarthritis have higher mean plasma MPO levels than patients with oligoarthritis and may therefore have an enhanced risk for subclinical oxidative stress-related atherogenic promotion.

Keywords

EN

Juvenile idiopathic arthritis; Myeloperoxidase

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2010
• Volume: 5
• Issue: 1
• Pages: 36-40

Dates

published

1 - 2 - 2010

online

29 - 1 - 2010

Contributors

author

Chris Pruunsild

• Department of Pediatrics, Tartu University, Lunini 6, Tartu, 51014, Estonia

author

Kaire Heilman

• Department of Pediatrics, Tartu University, Lunini 6, Tartu, 51014, Estonia

author

Kersti Zilmer

• Department of Biochemistry, Tartu University, Ravila 19, Tartu, 50411, Estonia

author

Karin Uibo

• Tallinn Children’s Hospital, Tervise 28, Tallinn, 13419, Estonia

author

Hille Liivamägi

• Children’s Clinic, Tartu University Hospital, Lunini 6, Tartu, 51014, Estonia

author

Tiina Talvik

• Department of Pediatrics, Tartu University, Lunini 6, Tartu, 51014, Estonia

author

Mihkel Zilmer

• Department of Biochemistry, Tartu University, Ravila 19, Tartu, 50411, Estonia

author

Vallo Tillmann

• Department of Pediatrics, Tartu University, Lunini 6, Tartu, 51014, Estonia

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Identifiers

DOI

10.2478/s11536-009-0107-5