Platelet indices in patients with colorectal cancer

• Authors: Bülent Karagöz , İlker Sücüllü , Özkan Sayan , Oğuz Bilgi , Tolga Tuncel , Ali Filiz , Ergün Yücel , Alpaslan Ozgun , Alev Erikçi , Ahmet Alacacioğlu , Emin Kandemir
• Languages of publication: EN

Abstracts

EN

The interaction between cancer cells and platelets has been known for a long time. Although platelet indices have been also investigated in several clinical settings, it has not been exactly demonstrated in cancer patients. We investigated platelet indices in colorectal cancer patients and compared with healthy subjects. Two hundred and twenty-one colorectal cancer patients and 110 healthy subjects were enrolled into the retrospective study. Data were obtained from computerized medical records of our hospital. Medical record review was performed for all patients regarding thrombocyte indices. Platelet count (325.000/mm3 ± 265.000/mm3 vs 267.000/mm3 ± 67.000/mm3; p=0.025; respectively) and plateletcrit (Pct) (0.25% ± 0.10 vs 0.21 ± 0.05; p<0.001; respectively) were increased in patients compared with healthy subjects while mean platelet volume (MPV) and platelet distribution width (PDW) were similar. The platelet indices were not related to existence of metastasis or acute abdomen. Platelet count and Pct, but not MPV and PDW, are elevated in colorectal cancer patients. Future studies that investigate platelet morphology, function, and putative role of platelets in tumorigenesis and metatasis should be established.

Keywords

EN

Colorectal carcinoma; Mean platelet volume; Platelet indices

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2010
• Volume: 5
• Issue: 3
• Pages: 365-368

Dates

published

1 - 6 - 2010

online

9 - 4 - 2010

Contributors

author

Bülent Karagöz

• Department of Medical Oncology, GATA Haydarpasa Training Hospital, 34668, Haydarpaşa, İstanbul, Turkey

author

İlker Sücüllü

• Department of General Surgery, GATA Haydarpasa Training Hospital, 34668, Haydarpaşa, İstanbul, Turkey

author

Özkan Sayan

• Department of Hematology, GATA Haydarpasa Training Hospital, 34668, Haydarpaşa, İstanbul, Turkey

author

Oğuz Bilgi

• Department of Medical Oncology, GATA Haydarpasa Training Hospital, 34668, Haydarpaşa, İstanbul, Turkey

author

Tolga Tuncel

• Department of Medical Oncology, GATA Haydarpasa Training Hospital, 34668, Haydarpaşa, İstanbul, Turkey

author

Ali Filiz

• Department of General Surgery, GATA Haydarpasa Training Hospital, 34668, Haydarpaşa, İstanbul, Turkey

author

Ergün Yücel

• Department of General Surgery, GATA Haydarpasa Training Hospital, 34668, Haydarpaşa, İstanbul, Turkey

author

Alpaslan Ozgun

• Department of Medical Oncology, GATA Haydarpasa Training Hospital, 34668, Haydarpaşa, İstanbul, Turkey

author

Alev Erikçi

• Department of Hematology, GATA Haydarpasa Training Hospital, 34668, Haydarpaşa, İstanbul, Turkey

author

Ahmet Alacacioğlu

• Department of Medical Oncology, GATA Haydarpasa Training Hospital, 34668, Haydarpaşa, İstanbul, Turkey

author

Emin Kandemir

• Department of Medical Oncology, GATA Haydarpasa Training Hospital, 34668, Haydarpaşa, İstanbul, Turkey

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Identifiers

DOI

10.2478/s11536-009-0077-7