Association of osteoprotegerin and rankl levels with insulin resistance in pubertal obese children

• Authors: Ediz Yeşilkaya , Aysun Bideci , Orhun Çamurdan , Mehmet Boyraz , Sebahattin Vurucu , Peyami Cinaz
• Languages of publication: EN

Abstracts

EN

Osteoprotegerin (OPG)/“receptor activator of nuclear factor kappa B-ligand” (RANKL) system has an important role in the remodeling of bone through regulation of osteoclastogenesis. We aimed to detect OPG and RANKL levels, particularly in obese children in the pubertal period and to investigate whether these parameters correlate with insulin resistance in childhood. Our study included 66 obese children ranging in age from 9.1 to 16 years, and 22 non-obese children ranging in age from 10.5 to 16 years. Blood glucose, insulin, total cholesterol, HDL cholesterol, and LDL cholesterol levels were measured for all cases; HOMA-IR, Quicki index and atherogenic index were calculated. Serum OPG and RANKL levels were also measured. OPG and RANKL levels did not show any difference between obese and non-obese children (P>.05). No difference in these 2 parameters were observed among the children with and without insulin resistance (P>.05). No correlation could be established between the OPG, the HOMA-IR, Quick and atherogenic indices. Obesity and insulin resistance are believed to show their effect in the later period of life to become able to change some of the parameters.

Keywords

EN

Henoch-Schönlein purpura; Nephrotic syndrome; Adulthood

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2010
• Volume: 5
• Issue: 2
• Pages: 261-267

Dates

published

1 - 4 - 2010

online

17 - 4 - 2010

Contributors

author

Ediz Yeşilkaya

• Department of Pediatric Endocrinology, Gazi University Medical School, 06200, Ankara, Turkey

author

Aysun Bideci

• Department of Pediatric Endocrinology, Gazi University Medical School, 06200, Ankara, Turkey

author

Orhun Çamurdan

• Department of Pediatric Endocrinology, Gazi University Medical School, 06200, Ankara, Turkey

author

Mehmet Boyraz

• Department of Pediatric Endocrinology, Gazi University Medical School, 06200, Ankara, Turkey

author

Sebahattin Vurucu

• Department of Pediatric Neurology, Gülhane Military Medical Academy, 06018, Ankara, Turkey

author

Peyami Cinaz

• Department of Pediatric Endocrinology, Gazi University Medical School, 06200, Ankara, Turkey

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Identifiers

DOI

10.2478/s11536-009-0065-y