How safe is the use of prosthetic materials in the repair of abdominal-wall defects in malnourished subjects?

• Authors: Mehmet Karahan , Hakan Kulacoglu , Duray Seker , Zafer Ergul , Aysel Kiziltay , Demet Yilmazer , Ozge Captug , Alper Yavuz , Kemal Serbetci , Hasan Bilgili , Nesrin Hasirci
• Languages of publication: EN

Abstracts

EN

Incisional hernias and abdominal-wall defects consume large amounts of healthcare resources. Use of mesh is effective in treatment of these disorders and can decrease the rate of recurrence. This experimental study focused on the safety of mesh use in the setting of malnutrition, a condition that impairs wound healing. Rats were divided into two groups: normally fed and food-restricted. An abdominal-wall defect, 2 by 2 cm, was covered with polypropylene mesh, 2.5 by 2.5 cm. After sacrifice of the rats at the 21st and 60th days, tissue samples were sent for tensiometric and histopathological studies. No significant difference in infectious complications was observed between the two groups. Tensiometry revealed no significant differences between the groups. On histopathological examination, the only difference noted was in the vascularization scores of normally fed rats. For malnourished subjects that survived after surgery, the use of polypropylene mesh appeared safe in the closure of abdominal-wall defects, with no increase in infection rate and satisfactory wound healing.

Keywords

EN

Hernia repair; Mesh; Wound healing; Tensile strength; Malnutrition

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2009
• Volume: 4
• Issue: 3
• Pages: 331-336

Dates

published

1 - 9 - 2009

online

3 - 7 - 2009

Contributors

author

Mehmet Karahan

• Deparment of Surgery, Diskapi Yildirim Beyazit Teaching and Research Hospital, 06110, Ankara, Turkey

author

Hakan Kulacoglu

• Deparment of Surgery, Diskapi Yildirim Beyazit Teaching and Research Hospital, 06110, Ankara, Turkey

author

Duray Seker

• Deparment of Surgery, Diskapi Yildirim Beyazit Teaching and Research Hospital, 06110, Ankara, Turkey

author

Zafer Ergul

• Deparment of Surgery, Diskapi Yildirim Beyazit Teaching and Research Hospital, 06110, Ankara, Turkey

author

Aysel Kiziltay

• Grad. Dept. Biotechnology, Middle East Technical University, 06530, Ankara, Turkey

author

Demet Yilmazer

• Deparment of Pathology, Diskapi Yildirim Beyazit Teaching and Research Hospital, 06110, Ankara, Turkey

author

Ozge Captug

• Department of Surgery, Ankara University Faculty of Veterinary Medicine, 06110, Ankara, Turkey

author

Alper Yavuz

• Deparment of Surgery, Diskapi Yildirim Beyazit Teaching and Research Hospital, 06110, Ankara, Turkey

author

Kemal Serbetci

• Baskent University Faculty of Biomedical Engineering, 06810, Ankara, Turkey

author

Hasan Bilgili

• Department of Surgery, Ankara University Faculty of Veterinary Medicine, 06110, Ankara, Turkey

author

Nesrin Hasirci

• Dept. Chemistry, Grad. Dept. Biotechnology, Grad Dept.Biomedical Engineering, Middle East Technical University, 06530, Ankara, Turkey

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Identifiers

DOI

10.2478/s11536-009-0029-2