Protective effect of L-carnitine against cisplatin-induced liver and kidney oxidant injury in rats

• Authors: Kerim Cayir , Ali Karadeniz , Abdulkadir Yildirim , Yildiray Kalkan , Akar Karakoc , Mustafa Keles , Salim Tekin
• Languages of publication: EN

Abstracts

EN

The present study was designed to investigate the protective effects of L-carnitine (LC) on changes in the levels of lipid peroxidation and endogenous antioxidants induced by cisplatin (cis-diamminedichloroplatinum II, CDDP) in the liver and kidney tissues of rats. Twenty-four Sprague Dawley rats were equally divided into four groups of six rats each: control, cisplatin, L-carnitine, and L-carnitine plus cisplatin. The degree of protection produced by L-carnitine was evaluated by determining the level of malondialdehyde (MDA). The activity of glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST), and superoxide dismutase (SOD) were estimated from liver and kidney homogenates, and the liver and kidney were histologically examined as well. L-carnitine elicited significant liver and kidney protective activity by decreasing the level of lipid peroxidation (MDA) and elevating the activity of GSH, GSHPx, GST, and SOD. Furthermore, these biochemical observations were supported by histological findings. In conclusion, the present study indicates a significant role for reactive oxygen species (ROS) and their relation to liver and kidney dysfunction, and points to the therapeutic potential of LC in CDDP-induced liver and kidney toxicity.

Keywords

EN

L-carnitine; Cisplatin; Liver; Kidney; Oxidative damage

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2009
• Volume: 4
• Issue: 2
• Pages: 184-191

Dates

published

1 - 6 - 2009

online

27 - 3 - 2009

Contributors

author

Kerim Cayir

• Department of Internal Medicine, Faculty of Medicine, University of Atatürk, 25700, Erzurum, Turkey

author

Ali Karadeniz

• Department of Physiology, Faculty of Veterinary Medicine, University of Atatürk, 25700, Erzurum, Turkey

author

Abdulkadir Yildirim

• Department of Biochemistry, Faculty of Medicine, University of Atatürk, 25700, Erzurum, Turkey

author

Yildiray Kalkan

• Department of Histology and Embryology, Faculty of Medicine, University of Atatürk, 25700, Erzurum, Turkey

author

Akar Karakoc

• Department of Biochemistry, Faculty of Medicine, University of Atatürk, 25700, Erzurum, Turkey

author

Mustafa Keles

• Department of Internal Medicine, Faculty of Medicine, University of Atatürk, 25700, Erzurum, Turkey

author

Salim Tekin

• Department of Internal Medicine, Faculty of Medicine, University of Atatürk, 25700, Erzurum, Turkey

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Identifiers

DOI

10.2478/s11536-009-0021-x