Serum levels of cortisol and prolactin in patients treated under total intravenous anesthesia with propofol-fentanyl and under balanced anesthesia with isoflurane-fentanyl

• Authors: Zlata Mujagić , Elsada Čičko , Vesna Vegar-Brozović , Mirsada Prašo
• Languages of publication: EN

Abstracts

EN

The study was designed to determine pre-, intra-and postoperative serum cortisol and prolactin (PRL) concentrations in patients subjected to low abdominal surgery under total intravenous anesthesia (TIVA) with propofol-fentanyl, and under general balanced anesthesia with isoflurane-fentanyl. The prospective study included 50 patients of both sexes, aged between 35 and 60 years, subjected to elective low abdominal surgery. Patients were randomly divided into two groups: an experimental group, consisting of 25 ASA I/II (American Society of Anesthesiologists I/II classification) patients treated under TIVA with propofol-fentanyl, and a control group consisting of 25 ASA I/II patients treated under balanced anesthesia with isoflurane-fentanyl. The length of the surgery and the degree of the surgical trauma did not differ significantly between the two anesthesia groups. Blood samples for cortisol and PRL measurements were drawn at exact time points: 30 minutes before the beginning of the surgery (T0), 30 minutes after the beginning of the surgery (T1), at the end of the surgery (T2), 2 hours after the surgery (T3), and 24 hours after the surgery (T4). Serum levels of cortisol and PRL were measured using commercially available kits. The results were evaluated with the nonparametric Mann-Whitney test. The serum concentration of cortisol measured at T1 time point in patients treated under TIVA was significantly lower (p=0.04) than that in patients treated under general balanced anesthesia. The average circulating levels of PRL measured at T1, T2 and T3 time points in patients treated under TIVA were significantly lower (p=0.003; p=0.002; p<0.05; respectively) than those in patients treated under balanced anesthesia. The results obtained suggest that the endocrine stress response developed in response to surgery is probably attenuated in patients treated under TIVA with propofol-fentanyl and, thus, that these patients are less stressed in comparison to patients treated under general balanced anesthesia with isoflurane-fentanyl.

Keywords

EN

Cortisol; Prolactin; Surgery; Propofol-fentanyl anesthesia; Isoflurane-fentanyl anesthesia

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2008
• Volume: 3
• Issue: 4
• Pages: 459-463

Dates

published

1 - 12 - 2008

online

22 - 10 - 2008

Contributors

author

Zlata Mujagić

• Chair in Biochemistry, Faculty of Pharmacy, University of Tuzla, Tuzla, Bosnia and Herzegowina

author

Elsada Čičko

• Clinic of Anaesthesiology and Reanimatology, University Clinical Center, Tuzla, Bosnia and Herzegowina

author

Vesna Vegar-Brozović

• Clinic of Anaesthesiology, Reanimatology and Intensive Care, University Hospital Centre, School of Medicine, Zagreb, Croatia

author

Mirsada Prašo

• Clinic of Anaesthesiology and Reanimatology, University Clinical Center, Tuzla, Bosnia and Herzegowina

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Identifiers

DOI

10.2478/s11536-008-0051-9