Comparison of octenidine dihydrochloride (Octenisept®), polihexanide (Prontosan®) and povidon iodine (Betadine®) for topical antibacterial effects in Pseudomonas aeruginosa-contaminated, full-skin thickness burn wounds in rats

• Authors: Fatih Uygur , Mustafa Özyurt , Rahmi Evinç , Tugrul Hosbul , Bahattin Çeliköz , Tuncer Haznedaroglu
• Languages of publication: EN

Abstracts

EN

Pseudomonas aeruginosa is one of the most frequently isolated organisms from infected burn wounds and a significant cause of nosocomial infection and septic mortality among burn patients. In this animal study, three antiseptic agents which were Octenidine dihydrochloride (Octenisept®, Schülke & Mayr, Norderstedt, Germany), polyhexanide (Prontosan®, B. Braun, Melsungen AG, Germany) and povidon iodine (Betadine, Purdue Pharma L.P, Stamford, USA) were compared to assess the antiseptic effect of their applications on experimental burn wounds in in rats contaiminated with P. aeruginosa. All treatment modalities were effective against P. aeruginosa because there were significant differences between treatment groups and control groups. The mean eschar concentrations were not different between polyhexanide and povidon iodine groups, but there were significant differences between the octenidine dihydrochloride group and the other treatment groups, indicating that the Octenidine dihydrochloride significantly eliminated P. aeruginosa more effectively in the tissues compared to the to other agents. All treatment modalities were sufficient to prevent the P. aeruginosa invasion into the muscle and to cause systemic infection. In conclusion, Octenidine dihydrochloride is the most effective antiseptic agent in the treatment of the P. aeruginosa-contaminated burn wounds; Octenidine dihydrochloride can be considered as a treatment choice because of its peculiar ability of limit the frequency of replacing wound dressings.

Keywords

EN

Pseudomonas aeruginosa; Burn wounds; Antiseptic

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2008
• Volume: 3
• Issue: 4
• Pages: 417-421

Dates

published

1 - 12 - 2008

online

22 - 10 - 2008

Contributors

author

Fatih Uygur

• Department of Plastic and Reconstructive Surgery and Burn Unit, Gülhane Military Medical Academy and Medical Faculty, Haydarpaşa Training Hospital, 34668, Istanbul, Turkey

author

Mustafa Özyurt

• Department of Microbiology and Clinical Microbiology, Gülhane Military Medical Academy and Medical Faculty, Haydarpaşa Training Hospital, 34668, Istanbul, Turkey

author

Rahmi Evinç

• Department of Plastic and Reconstructive Surgery and Burn Unit, Gülhane Military Medical Academy and Medical Faculty, Haydarpaşa Training Hospital, 34668, Istanbul, Turkey

author

Tugrul Hosbul

• Department of Microbiology and Clinical Microbiology, Gülhane Military Medical Academy and Medical Faculty, Haydarpaşa Training Hospital, 34668, Istanbul, Turkey

author

Bahattin Çeliköz

• Department of Plastic and Reconstructive Surgery and Burn Unit, Gülhane Military Medical Academy and Medical Faculty, Haydarpaşa Training Hospital, 34668, Istanbul, Turkey

author

Tuncer Haznedaroglu

• Department of Microbiology and Clinical Microbiology, Gülhane Military Medical Academy and Medical Faculty, Haydarpaşa Training Hospital, 34668, Istanbul, Turkey

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Identifiers

DOI

10.2478/s11536-008-0042-x