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Number of results

Journal

2008 | 3 | 2 | 215-220

Article title

Successful management of mild atopic dermatitis in adults with probiotics and emollients

Content

Title variants

Languages of publication

EN

Abstracts

EN
Atopic dermatitis is characterized by impaired skin and mucous membrane barrier function. Measures improving barrier integrity decrease the influence of environmental factors that might exacerbate inflammation. Ten adult patients with mild-to-moderate atopic dermatitis consumed for three months fermented with potent antioxidative probiotic, L. fermentum ME-3 (DSM 14241) goat milk 200 mg/day. A control group consisted of six patients, not supplemented by probiotic. All patients used emollients regularly. Skin iron levels, glutathione redox ratios (GSSG/GSH), diene conjugate (DC) amounts, blood glutathione status, oxidized low-density lipoprotein (oxLDL), and total antioxidativity was measured at the baseline and after three months. A significant decrease in skin iron levels, DC amounts, and glutathione redox ratio occurred in the probiotic-supplemented group compared to the control group (P < 0.05 for all indices). In the same group, blood levels of oxLDL decreased (p < 0.05), and GSH levels increased (P < 0.001) with concomitant improvement in the GSSG/GSH ratio. Blood antioxidativity markers also showed an improvement. The results of our study demonstrate that regular use of probiotics with antioxidative properties coupled with the use of lipid-containing emollients considerably decreases inflammation and concomitant oxidative stress in adult patients with mild-to-moderate atopic dermatitis. This effect was observed both in the skin and in the blood.

Publisher

Journal

Year

Volume

3

Issue

2

Pages

215-220

Physical description

Dates

published
1 - 6 - 2008
online
9 - 4 - 2008

Contributors

author
  • Clinic of Dermatology, Faculty of Medicine, University of Tartu, 50417, Tartu, Estonia
  • Institute of Biochemistry, Faculty of Medicine, University of Tartu, 50417, Tartu, Estonia
  • Institute of Microbiology, Faculty of Medicine, University of Tartu, 50417, Tartu, Estonia
author
  • Clinic of Dermatology, Faculty of Medicine, University of Tartu, 50417, Tartu, Estonia
author
  • Institute of Biochemistry, Faculty of Medicine, University of Tartu, 50417, Tartu, Estonia
author
  • Institute of Biochemistry, Faculty of Medicine, University of Tartu, 50417, Tartu, Estonia
author
  • Institute of Biochemistry, Faculty of Medicine, University of Tartu, 50417, Tartu, Estonia
author
  • Institute of Biochemistry, Faculty of Medicine, University of Tartu, 50417, Tartu, Estonia

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11536-008-0022-1
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