Detection and identification of atypical quetiapine metabolite in urine

• Authors: Vasil Atanasov , Kamen Kanev , Mariana Mitewa
• Languages of publication: EN

Abstracts

EN

Quetiapine fumarate (Seroquel®) is an atypical antipsychotic dibenzothiazepine derivative. Due to its extensive hepatic metabolism and low level of unchanged excretion (< 1%) the routine toxicological drug-screening analyses of urine often leads to false negative results. In the present study, we report that a newly identified metabolite of quetiapine, N-desalkylquetiapine, can be used as an indicative marker of quetiapine-intake in urine using common GC-MS screening procedure. The structure of the mentioned metabolite was solved from the mass-spectrum obtained and the quetiapine presence was proved by consequent HPLC plasma analysis.

Keywords

EN

Quetiapine; N-desalkylquetiapine; GC-MS screening

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2008
• Volume: 3
• Issue: 3
• Pages: 327-331

Dates

published

1 - 9 - 2008

online

10 - 7 - 2008

Contributors

author

Vasil Atanasov

author

Kamen Kanev

• Clinic of Emergency Toxicology and Allergology, Military Medical Academy, 3 G. Sofiiski Str, 1603, Sofia, Bulgaria

author

Mariana Mitewa

• Laboratory of Bioinorganic and Bioanalytical Chemistry, Department of Analytical Chemistry, Faculty of Chemistry, Sofia University, 1 J. Bourchier Ave., 1164, Sofia, Bulgaria

References

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Identifiers

DOI

10.2478/s11536-008-0015-0