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Number of results

Journal

2008 | 3 | 3 | 358-360

Article title

Risk factors in a patient with fungemia caused by fluconazole-resistant Candida albicans

Content

Title variants

Languages of publication

EN

Abstracts

EN
Blood stream infections due to Candida species are becoming increasingly important causes of morbidity and mortality in hospitalized patients. Risk factors that predispose patients to developing invasive Candida infections have been documented as, iatrogenic and/or nosocomial conditions and immunosuppression. In the present report, we want to emphasize the risk factors that predispose individuals to the development of candidemia, particularly those that are relevant to our patient. We describe a female patient with diabetes mellitus who had been receiving glucocorticoids for 20 years as replacement therapy for hypopituitarism resulting from hypophysis adenoma surgery. The patient received antibiotic therapy for recurrent wound infections and was hospitalized for a long time, including a period in the intensive care unit and instrumented. The patient eventually succumbed to fungemia caused by a fluconazole-resistant strain of C. albicans strain.

Publisher

Journal

Year

Volume

3

Issue

3

Pages

358-360

Physical description

Dates

published
1 - 9 - 2008
online
10 - 7 - 2008

Contributors

author
  • Department of Microbiology and Clinical Microbiology, Medical Faculty, Duzce University, Duzce, Turkey
  • Department of Microbiology and Clinical Microbiology, Medical Faculty, Duzce University, Duzce, Turkey
author
  • Department of Orthopaedics and Traumatology, Medical Faculty, Duzce University, Duzce, Turkey

References

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  • [4] Wisplinghoff H., Bischoff T., Tallent S.M., Seifert H., Wenzel R.P., Edmond M.B., Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study, Clin. Infect. Dis., 2004, 39, 309–317 http://dx.doi.org/10.1086/421946[Crossref]
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  • [9] Moutschen M.P., Scheen A.J., Lefebvre P.J. Impaired immune responses in diabetes mellitus: analysis of the factors and mechanisms involved. Relevance to the increased susceptibility of diabetic patients to specific infections, Diabetes Metab., 1992, 18, 187–201
  • [10] Heidenreich S., Kubis T., Schmidt M., Fegeler W., Glucocorticoid-induced alterations of monocyte defense mechanisms against Candida albicans, Cell. Immunol., 1994, 157, 320–327 http://dx.doi.org/10.1006/cimm.1994.1230[Crossref]
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  • [12] Yeast-Candida., available in the nutramed database (http://www.nutramed.com/allergy/candida.htm)
  • [13] Wisplinghoff H., Bischoff T., Tallent S.M., Seifert H., Wenzel R.P., Edmond M.B., Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study, Clin. Infect. Dis., 2004, 39, 309–317 http://dx.doi.org/10.1086/421946[Crossref]
  • [14] Pappas P.G., Rex J.H., Sobel J.D., Filler S.G., Dismukes W.E., Walsh T.J., et al., “Infectious Diseases Society of America: guidelines for treatment of candidiasis”, Clin. Infect. Dis., 2004, 38, 161–189 http://dx.doi.org/10.1086/380796[Crossref]
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  • [17] Maida C.M., Milici M.E., Oliveri S., In vitro activity of fluconazole, voriconazole and caspofungin against clinical yeast isolates, J. Chemother., 2007, 19, 277–82

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11536-008-0004-3
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