Monocyte and neutrophil direct counts correlate with C-reactive protein plasma concentration in patients with acute pancreatitis

• Authors: Jerzy Naskalski , Barbara Maziarz , Beata Kusnierz-Cabala , Paulina Dumnicka , Józefa Panek
• Languages of publication: EN

Abstracts

EN

Acute pancreatitis (AP) is associated with the intensive inflammatory response in white blood cells (WBC) and C-reactive protein (CRP). This paper presents the relationship between the CRP plasma concentration and the direct counts of peripheral WBC in AP during the initial five days. The study consisted of 56 patients with AP, 36 patients with mild form of AP and 20 patients with severe form of AP. ABX VegaRetic hematological analyzer was used to perform the count of blood cells, and the immunonephelometric method was performed to measure the CRP concentration levels. AP patients presented with WBC count values in the range of 3.2 − 22.4 × 103/µl and CRP concentration levels in the range 3.3 − 599.8 mg/l. The WBC count correlates with CRP levels during the entire observation period. The relationship of CRP and WBC is expressed in the following regression equation: WBC (103/µl) = 3.66 + 1.40 × logeCRP (mg/l). The highest median neutrophil count (8.15 × 103/µl) was observed on the first day. The count decreased to 5.27 × 103/µl on the fifth day. The most substantial finding in this study involved the values found for the monocytes and CRP (r= 0.53; p<0.001). Day two and day three were the highest (r=0.59, p<0.001). On day two, the regression equation for this relationship is: Monocytes (103/µl) = −0.34 + 0.21 × logeCRP(mg/l). The correlation between direct monocyte count and plasma CRP concentration in AP reflect a CRP-dependent stimulation of IL-6 release from activated blood monocytes.

Keywords

EN

Acute pancreatitis; white blood cells; inflammation

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2007
• Volume: 2
• Issue: 1
• Pages: 26-36

Dates

published

1 - 3 - 2007

online

1 - 3 - 2007

Contributors

author

Jerzy Naskalski

• Department of Clinical Biochemistry, Collegium Medicum Jagiellonian University, 31-501, Kraków, Poland

author

Barbara Maziarz

• Department of Clinical Biochemistry, Collegium Medicum Jagiellonian University, 31-501, Kraków, Poland

author

Beata Kusnierz-Cabala

• Department of Clinical Biochemistry, Collegium Medicum Jagiellonian University, 31-501, Kraków, Poland

author

Paulina Dumnicka

• Department of Clinical Biochemistry, Collegium Medicum Jagiellonian University, 31-501, Kraków, Poland

author

Józefa Panek

• IInd Department of General Surgery, Collegium Medicum, Jagiellonian University, 31-501, Kraków, Poland

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Identifiers

DOI

10.2478/s11536-007-0008-4