MCNP simulation of the dose distribution in liver cancer treatment for BNC therapy

• Authors: Dragana Krstic , Zoran Jovanovic , Vladimir Markovic , Dragoslav Nikezic , Vlade Urosevic
• Languages of publication: EN

Abstracts

EN

The Boron Neutron Capture Therapy (BNCT) is based on selective uptake of boron in tumour tissue compared to the surrounding normal tissue. Infusion of compounds with boron is followed by irradiation with neutrons. Neutron capture on 10B, which gives rise to an alpha particle and recoiled 7Li ion, enables the therapeutic dose to be delivered to tumour tissue while healthy tissue can be spared. Here, therapeutic abilities of BNCT were studied for possible treatment of liver cancer using thermal and epithermal neutron beam. For neutron transport MCNP software was used and doses in organs of interest in ORNL phantom were evaluated. Phantom organs were filled with voxels in order to obtain depth-dose distributions in them. The result suggests that BNCT using an epithermal neutron beam could be applied for liver cancer treatment.

Keywords

EN

Boron Neutron Capture Therapy (BNCT); Monte Carlo simulation; depth-dose distributions; liver cancer

• Publisher: De Gruyter Open
• Journal: Open Physics
• Year: 2014
• Volume: 12
• Issue: 10
• Pages: 714-718

Dates

published

1 - 10 - 2014

online

16 - 8 - 2014

Contributors

author

Dragana Krstic

• Faculty of Science, University of Kragujevac, R. Domanovica 12, 34000, Kragujevac, Serbia

author

Zoran Jovanovic

• Faculty of Science, University of Kragujevac, R. Domanovica 12, 34000, Kragujevac, Serbia

author

Vladimir Markovic

• Faculty of Science, University of Kragujevac, R. Domanovica 12, 34000, Kragujevac, Serbia

author

Dragoslav Nikezic

• Faculty of Science, University of Kragujevac, R. Domanovica 12, 34000, Kragujevac, Serbia

author

Vlade Urosevic

• Faculty of Technical Science, University of Kragujevac, Svetog Save 65, 32000, Cacak, Serbia

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Identifiers

DOI

10.2478/s11534-014-0507-2