Kinetics of the maintenance of the epidermis

• Authors: Vladimir Zhdanov , Nam-Joon Cho
• Languages of publication: EN

Abstracts

EN

The epidermis is the outermost layer of skin. It is comprised of keratin-containing cells called keratinocytes. Functionally, the epidermis serves as a physical barrier that can prevent infection and regulate body hydration. Maintenance and repair of the epidermis are important for human health. Mechanistically, these processes occur primarily via proliferation and differentiation of stem cells located in the basal monolayer. These processes are believed to depend on cell-cell communication and spatial constraints but existing kinetic models focus mainly on proliferation and differentiation. To address this issue, we present a mean-field kinetic model that takes these additional factors into account and describes the epidermis at a biosystem level. The corresponding equations operate with the populations of stem cells and differentiated cells in the basal layer. The keratinocytes located above the basal layer are treated at a more coarse-grained level by considering the thickness of the epidermis. The model clarifies the likely role of various negative feedbacks that may control the epidermis and, accordingly, provides insight into the cellular mechanisms underlying complex biological phenomena such as wound healing.

Keywords

EN

systems biology; biological kinetics; skin epidermis; stem cells; cell-cell communication

• Publisher: De Gruyter Open
• Journal: Open Physics
• Year: 2013
• Volume: 11
• Issue: 8
• Pages: 1016-1023

Dates

published

1 - 8 - 2013

online

23 - 10 - 2013

Contributors

author

Vladimir Zhdanov

author

Nam-Joon Cho

• School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Nanyang, Singapore

References

• [1] M.E. Csete, J.C. Doyle, Science 333, 1244 (2002)
• [2] N. Nandagopal, M.B. Elowitz, Science 333, 1244 (2011) http://dx.doi.org/10.1126/science.1207084[Crossref]
• [3] T. Afroz, C.L. Beisel, Chem. Eng. Sci. (2013), in press, http://dx.doi.org/10.1016/j.ces.2013.02.017i [Crossref]
• [4] R.L. Eckert et al., Biochim. Biophys. Acta 1830, 2427 (2013) http://dx.doi.org/10.1016/j.bbagen.2012.07.002[Crossref]
• [5] M.V. Plikus, D.L. Gay, E. Treffeisen, A. Wang, R.J. Supapannachart, G. Cotsarelis, Semin. Cell Dev. Biol. 23, 946 (2012) http://dx.doi.org/10.1016/j.semcdb.2012.10.001[Crossref]
• [6] S. Liu, H. Zhang, E. Duan, Int. J. Mol. Sci. 14, 10869 (2013) http://dx.doi.org/10.3390/ijms140610869[Crossref]
• [7] L. de Rosa, M. de Luca, Nature 489, 215 (2012) http://dx.doi.org/10.1038/489215a[Crossref]
• [8] C.S. Potten, M. Loeffler, Virchows Arch. B 53, 279 (1987) http://dx.doi.org/10.1007/BF02890254[Crossref]
• [9] E. Clayton, D.P. Doupe, A.M. Klein, D.J. Winton, B.D. Simons, P.H. Jones, Nature 446, 185 (2007) http://dx.doi.org/10.1038/nature05574[Crossref]
• [10] G. Mascre et al., Nature 489, 257 (2012) http://dx.doi.org/10.1038/nature11393[Crossref]
• [11] K.W. Mulder et al., Nat. Cell Biol. 14, 753 (2012) http://dx.doi.org/10.1038/ncb2520[Crossref]
• [12] T. Vazin, D.V. Schaffer, Trends Biotechnol. 28, 117 (2010) http://dx.doi.org/10.1016/j.tibtech.2009.11.008[Crossref]
• [13] D.E. Discher, D.J. Mooney, P.W. Zandstra, Science 324, 1673 (2009) http://dx.doi.org/10.1126/science.1171643[Crossref]
• [14] M. Levin, Progr. Biophys. Molec. Biol. 94, 186 (2007) http://dx.doi.org/10.1016/j.pbiomolbio.2007.03.005[Crossref]
• [15] J. Wu, M.R. Rostami, E.S. Tzanakakis, Curr. Opin. Chem. Eng. 2, 17 (2013) http://dx.doi.org/10.1016/j.coche.2013.01.001[Crossref]
• [16] S. Pastore, F. Mascia, V. Mariani, G. Girolomoni, J. Invest. Dermatol. 128, 1365 (2008) http://dx.doi.org/10.1038/sj.jid.5701184[Crossref]
• [17] A. Celli, S. Sanchez, M. Behne, T. Hazlett, E. Gratton, T. Mauro, Biophys. J. 98, 911 (2010) http://dx.doi.org/10.1016/j.bpj.2009.10.055[Crossref]
• [18] M. Kurasawa, T. Maeda, A. Oba, T. Yamamoto, H. Sasaki, Biochem. Bioph. Res. Co. 406, 506 (2011) http://dx.doi.org/10.1016/j.bbrc.2011.02.057[Crossref]
• [19] S. Lin, B. Wang, S. Getsios, Semin. Cell Dev. Biol. 23, 92 (2012) http://dx.doi.org/10.1016/j.semcdb.2011.10.017[Crossref]
• [20] K.R. Ryan, F.E. Lock, J.K. Heath, N.A. Hotchin, J. Cell Sci. 125, 3202 (2012) http://dx.doi.org/10.1242/jcs.101931[Crossref]
• [21] M. Loeffler, C.S. Potten, and H.E. Wichmann, Virchows Arch. B 53, 286 (1987) http://dx.doi.org/10.1007/BF02890255[Crossref]
• [22] N.J. Savill, Cell Prolif. 36, 1 (2003) http://dx.doi.org/10.1046/j.1365-2184.2003.00257.x[Crossref]
• [23] A.M. Klein, D.P. Doupe, P.H. Jones, B.D. Simons, Phys. Rev. E 76, 021910 (2007) http://dx.doi.org/10.1103/PhysRevE.76.021910[Crossref]
• [24] A.M. Klein, D.P. Doupe, P.H. Jones, B.D. Simons, Phys. Rev. E 77, 031907 (2007) http://dx.doi.org/10.1103/PhysRevE.77.031907[Crossref]
• [25] P.B. Warren, Phys. Rev. E 80, 030903 (2009) http://dx.doi.org/10.1103/PhysRevE.80.030903[Crossref]
• [26] C.F. Lee, Phys. Rev. E 82, 021103 (2010) http://dx.doi.org/10.1103/PhysRevE.82.021103[Crossref]
• [27] A. Gandolfi, M. Iannelli, G. Marinoschi, J. Math. Biol. 62, 111 (2011) http://dx.doi.org/10.1007/s00285-010-0330-3[Crossref]
• [28] J.Y. Chang, P.-Y. Lai, Phys. Rev. E 85, 041926 (2012) http://dx.doi.org/10.1103/PhysRevE.85.041926[Crossref]
• [29] X. Li et al., Sci. Rep. 3, 1904 (2013) [PubMed]
• [30] S. Nakaoka, K. Aihara, J. Math. Biol. 66, 807 (2013) http://dx.doi.org/10.1007/s00285-012-0618-6[Crossref]
• [31] A. Tsoularis, J. Wallace, Math. Biosci. 179, 21 (2002) http://dx.doi.org/10.1016/S0025-5564(02)00096-2[Crossref]
• [32] A. Marciniak-Czochra, T. Stiehl, A.D. Ho, W. Jäger, W. Wagner, Stem Cells Dev. 18, 377 (2009) http://dx.doi.org/10.1089/scd.2008.0143[Crossref]
• [33] Z. Sun, N.L. Komarova, Math. Biosci. 240, 231 (2012) http://dx.doi.org/10.1016/j.mbs.2012.08.004[Crossref]
• [34] V.P. Zhdanov, Chem. Phys. Lett. 437, 253 (2007) http://dx.doi.org/10.1016/j.cplett.2007.02.037[Crossref]
• [35] V.P. Zhdanov, B. Kasemo, Phys. Chem. Chem. Phys. 5, 1433 (2003) http://dx.doi.org/10.1039/b300087g[Crossref]
• [36] V.P. Zhdanov, B. Kasemo, Phys. Chem. Chem. Phys. 6, 138 (2004) http://dx.doi.org/10.1039/b311073g[Crossref]
• [37] G.K. Menon, P.M. Elias, K.R. Feingold, Brit. J. Dermatol. 130, 139 (1994) http://dx.doi.org/10.1111/j.1365-2133.1994.tb02892.x[Crossref]
• [38] M.J. Behne, J.-M. Jensen, Adv. Exp. Med. Biol. 740, 945 (2012) http://dx.doi.org/10.1007/978-94-007-2888-2_43[Crossref]
• [39] M.P. Adams, D.G. Mallet, G.J. Pettet, J. Theor. Biol. 301, 112 (2012) http://dx.doi.org/10.1016/j.jtbi.2012.02.017[Crossref]
• [40] S.Y. Shvartsman, AIChE Journal 51, 1312 (2005) http://dx.doi.org/10.1002/aic.10525[Crossref]
• [41] V.P. Zhdanov, B. Kasemo. Phys. Rev. E 74, 021915 (2006) http://dx.doi.org/10.1103/PhysRevE.74.021915[Crossref]
• [42] A. Traulsen, J.M. Pacheco, D. Dingli, Stem Cells 25, 3081 (2007) http://dx.doi.org/10.1634/stemcells.2007-0427[Crossref]

Identifiers

DOI

10.2478/s11534-013-0292-3