A generic 3D kinetic model of gene expression

• Authors: Vladimir Zhdanov
• Languages of publication: EN

Abstracts

EN

Recent experiments show that mRNAs and proteins can be localized both in prokaryotic and eukaryotic cells. To describe such situations, I present a 3D mean-field kinetic model aimed primarily at gene expression in prokaryotic cells, including the formation of mRNA, its translation into protein, and slow diffusion of these species. Under steady-state conditions, the mRNA and protein spatial distribution is described by simple exponential functions. The protein concentration near the gene transcribed into mRNA is shown to depend on the protein and mRNA diffusion coefficients and degradation rate constants.

Keywords

EN

subcellular processes; gene transcription; mRNA synthesis; mRNA translation; mRNA and protein diffusion and degradation

• Publisher: De Gruyter Open
• Journal: Open Physics
• Year: 2012
• Volume: 10
• Issue: 2
• Pages: 533-537

Dates

published

1 - 4 - 2012

online

31 - 3 - 2012

Contributors

author

Vladimir Zhdanov

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Identifiers

DOI

10.2478/s11534-012-0011-5