Merging of viral concentration waves in retrograde viral transport in axons

• Authors: Andrey Kuznetsov
• Languages of publication: EN

Abstracts

EN

This paper develops an analytical solution describing propagation of two viral waves in an axon and applies the obtained analytical solution to investigating the dynamics of merging of these two waves as they move retrogradely toward the neuron body. The viral diffusivity and viral degradation are accounted for in the model. Computational results are presented for two situations: when all dynein motors move with the same velocity and when dynein motor velocity distribution is characterized by a probability density function (pdf). The effect of various model parameters on the time it takes for the waves to merge is discussed. It is proposed that observing the dynamics of wave merging can be used for determining parameters characterizing viral transport, such as the viral diffusivity. This may contribute toward better understanding of viral transport properties and potentially help in developing novel viral detection techniques.

Keywords

EN

neurotropic virus; retrograde axonal transport; molecular motors; virus trafficking

• Publisher: De Gruyter Open
• Journal: Open Physics
• Year: 2011
• Volume: 9
• Issue: 6
• Pages: 1493-1502

Dates

published

1 - 12 - 2011

online

15 - 10 - 2011

Contributors

author

Andrey Kuznetsov

• Dept. of Mechanical and Aerospace Engineering, North Carolina State University, Campus Box 7910, NC, 27695-7910, Raleigh, USA

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Identifiers

DOI

10.2478/s11534-011-0070-z